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Title: Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners.
Authors: Iuliano-Burns, Sandra;Ayton, J;Hillam, S;Jones, G;King, K;Macleod, S;Seeman, Ego
Affiliation: Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 4-Jan-2012
Citation: Osteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa 2012; 23(10): 2461-7
Abstract: Sunlight deprivation results in vitamin D deficiency but serum vitamin D levels can be maintained above 50 nmol/L when supplemented with 50,000 IU at least every alternate month.Antarctic expeditioners are exposed to prolonged sunlight deprivation resulting in vitamin D deficiency. We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective.This was a randomised double-blind study involving 110 healthy adults: 91 males, mean age 41 years (range 24-65 years) working in Antarctica for up to 12 months, who we administered 50,000 IU vitamin D3 monthly, alternate months or a single dose pre-departure. Serum 25(OH)D, PTH, osteocalcin, CTx and calcium were assessed at baseline, mid- and end of expedition. Proximal femur and lumbar spine BMD were assessed pre- and post-expedition.Baseline 25(OH)D was 59 ± 14 nmol/L. By mid-expedition, 25(OH)D increased by 7 nmol/L in those supplemented monthly (p < 0.05) and remained unchanged in those supplemented in alternate months. In those given a single dose pre-departure, 25(OH)D decreased by 8 nmol/L (p < 0.05) and PTH increased by 27% (p < 0.09). Serum osteocalcin increased by ~22% in all groups but BMD remained unchanged. If serum 25(OH)D was >50 nmol/L at baseline, 25(OH)D was maintained above this level with all regimens. If 25(OH)D was <50 nmol/L at baseline, monthly or alternate month regimens were needed to achieve levels >50 nmol/L, the single pre-departure dose was ineffective.During sunlight deprivation of up to 12 months, serum 25(OH)D levels can be maintained above 50 nmol/L when expeditioners are provided with 50,000 I U at least every alternate month.
Internal ID Number: 22215183
DOI: 10.1007/s00198-011-1858-9
Type: Journal Article
Subjects: Adult
Antarctic Regions
Dietary Supplements
Double-Blind Method
Drug Administration Schedule
Lumbar Vertebrae.physiopathology
Middle Aged
Parathyroid Hormone.blood
Vitamin D.administration & dosage.analogs & derivatives.blood.therapeutic use
Vitamin D Deficiency.complications.physiopathology.prevention & control
Young Adult
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