Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11293
Title: Glomerular filtration rate in streptozocin-induced diabetic rats. Role of exchangeable sodium, vasoactive hormones, and insulin therapy.
Authors: Allen, Terri J;Cooper, Mark E;O'Brien, R C;Bach, Leon A;Jackson, B;Jerums, George
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Oct-1990
Citation: Diabetes; 39(10): 1182-90
Abstract: The interrelationships of sodium and volume status, atrial natriuretic peptide (ANP), plasma renin activity (PRA), insulinlike growth factor I (IGF-I), and kidney weight and their influence on glomerular filtration rate (GFR) were investigated in rats during the first 4 wk of streptozocin-induced diabetes (STZ-D). In each of three experiments, untreated diabetic rats were compared with nondiabetic control rats and rats with varying degrees of glycemic control during insulin therapy. The first experiment evaluated exchangeable sodium, plasma volume, and GFR. In untreated diabetic rats, exchangeable sodium and plasma volume, but not GFR, were increased by approximately 25% compared with control rats. Insulin-treated diabetic rats with plasma glucose levels ranging from 12 to 30 mM had increased GFR, whereas exchangeable sodium and plasma volume were reduced toward control values. Daily insulin therapy, titrated to maintain euglycemia, further reduced exchangeable sodium and plasma volume and decreased but did not normalize GFR. The second experiment evaluated the relationship between vasoactive hormones and GFR. In untreated diabetic rats, plasma ANP levels increased 89% and urinary cyclic GMP (cGMP) excretion increased 94%, with an 85% decrease in PRA, whereas GFR was unchanged. Moderate hyperglycemia (plasma glucose 12-30 mM) was associated with normalized plasma ANP levels and urinary cGMP excretion, a 52% decrease in PRA, and a 13% increase in GFR. The third experiment studied serial changes in food and water intake and vasoactive hormones and end-point measurement of kidney weight, GFR, and plasma IGF-I. In the untreated diabetic group, urinary cGMP excretion was significantly elevated after 3 wk, whereas the reduction in PRA levels was apparent after 1 wk.(ABSTRACT TRUNCATED AT 250 WORDS)
Internal ID Number: 2170215
URI: http://ahro.austin.org.au/austinjspui/handle/1/11293
URL: http://www.ncbi.nlm.nih.gov/pubmed/2170215
Type: Journal Article
Subjects: Animals
Atrial Natriuretic Factor.blood
Blood Glucose.metabolism
Cyclic GMP.urine
Diabetes Mellitus, Experimental.drug therapy.physiopathology
Glomerular Filtration Rate
Insulin.therapeutic use
Insulin-Like Growth Factor I.metabolism
Kidney.physiopathology
Male
Organ Size
Rats
Rats, Inbred Strains
Renin.blood
Sodium.metabolism
Appears in Collections:Journal articles

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