Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11280
Title: Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency.
Authors: Kovac, Suzana;Anderson, Gregory J;Alexander, Warren S;Shulkes, Arthur;Baldwin, Graham S
Affiliation: University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia. kovacs@unimelb.edu.au
Issue Date: 7-Jun-2011
Citation: Endocrinology 2011; 152(8): 3062-73
Abstract: Gastrins are peptide hormones important for gastric acid secretion and growth of the gastrointestinal mucosa. We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin concentrations positively correlate with transferrin saturation in vivo. Here we report the effect of long-term dietary iron modification on gastrin-deficient (Gas(-/-)) and hypergastrinemic cholecystokinin receptor 2-deficient (Cck2r(-/-)) mice, both of which have reduced basal gastric acid secretion. Iron homeostasis in both strains appeared normal unless the animals were challenged by iron deficiency. When fed an iron-deficient diet, Gas(-/-) mice, but not Cck2r(-/-) mice, developed severe anemia. In iron-deficient Gas(-/-) mice, massive splenomegaly was also apparent with an increased number of splenic megakaryocytes accompanied by thrombocytosis. The expression of the mRNA encoding the iron-regulatory peptide hepcidin, Hamp, was down-regulated in both Cck2r(-/-) and Gas(-/-) mice on a low-iron diet, but, interestingly, the reduction was greater in Cck2r(-/-) mice and smaller in Gas(-/-) mice than in the corresponding wild-type strains. These data suggest that gastrins play an important direct role, unrelated to their ability to stimulate acid secretion, in hematopoiesis under conditions of iron deficiency.
Internal ID Number: 21652729
URI: http://ahro.austin.org.au/austinjspui/handle/1/11280
DOI: 10.1210/en.2010-1474
URL: http://www.ncbi.nlm.nih.gov/pubmed/21652729
Type: Journal Article
Subjects: Animals
Antimicrobial Cationic Peptides.genetics
Cation Transport Proteins.genetics
Erythropoietin.blood
Gastrins.blood.deficiency
Hematopoiesis
Hepcidins
Iron.deficiency
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Receptor, Cholecystokinin B.physiology
Splenomegaly.etiology
Thrombopoietin.blood
Appears in Collections:Journal articles

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