Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11265
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dc.contributor.authorWiddop, Robert Een
dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorJarrott, Ben
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T00:51:15Z
dc.date.available2015-05-16T00:51:15Z
dc.date.issued1990-03-01en
dc.identifier.citationJournal of Hypertension; 8(3): 269-75en
dc.identifier.govdoc2159508en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11265en
dc.description.abstractThe activity of baroreceptor reflexes and cardiopulmonary reflexes was examined in conscious spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats. The baroreceptor heart rate reflex, elicited by phenylephrine- and nitroprusside-induced changes in blood pressure, had a reduced range and lower heart rate plateau in SHR than in WKY rats, which suggests impaired vagal control of the heart rate in SHR. Cardiopulmonary receptor reflex activity was assessed by intravenous injections of phenyldiguanide which evoke the Bezold-Jarisch reflex. Phenyldiguanide elicited dose-dependent bradycardic and hypotensive responses in WKY rats, but these were significantly attenuated in SHR. This is the first demonstration of impaired Bezold-Jarisch responses in conscious SHR and provides evidence of both impaired vagally mediated arterial baroreceptor activity and impaired cardiopulmonary receptor activity in this rat strain.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherArteries.innervationen
dc.subject.otherBiguanides.administration & dosage.pharmacologyen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherDose-Response Relationship, Drugen
dc.subject.otherFemaleen
dc.subject.otherHeart.innervationen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherHypertension.physiopathologyen
dc.subject.otherLung.innervationen
dc.subject.otherPressoreceptors.drug effects.physiopathologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherReflex, Abnormal.drug effectsen
dc.subject.otherVagus Nerve.physiopathologyen
dc.titleImpaired arterial baroreceptor reflex and cardiopulmonary vagal reflex in conscious spontaneously hypertensive rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of hypertensionen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages269-75en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/2159508en
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