Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11259
Title: 125I-endothelin-1 binding to brain and cardiac membranes from normotensive and spontaneously hypertensive rats.
Authors: Gu, X H;Casley, David J;Cincotta, M;Nayler, W G
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 27-Feb-1990
Citation: European Journal of Pharmacology; 177(3): 205-9
Abstract: 125I-labelled endothelin-1 was used to identify specific high affinity endothelin-1 binding sites in left ventricular and brain membranes harvested from female age-matched normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Relative to results obtained for brain membranes from normotensive rats, brain membranes from hypertensive rats exhibited an increase in 125I-endothelin-1 binding site density (P less than 0.02). In left ventricular membranes from the hypertensive rats 125I-endothelin-1 binding site density was reduced (P less than 0.02), relative to the density in ventricular membranes of normotensive rats. These results indicate that hypertension may have an organ specific effect on 125I-endothelin-1 binding site density.
Internal ID Number: 2155810
URI: http://ahro.austin.org.au/austinjspui/handle/1/11259
URL: http://www.ncbi.nlm.nih.gov/pubmed/2155810
Type: Journal Article
Subjects: Animals
Blood Pressure
Brain.metabolism
Endothelins
Female
Heart Rate
Hypertension.metabolism
Iodine Radioisotopes.diagnostic use
Kinetics
Membranes.metabolism
Myocardial Contraction
Myocardium.metabolism
Organ Size
Peptides.metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Cell Surface.metabolism
Receptors, Endothelin
Appears in Collections:Journal articles

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