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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kelly, J M | en |
dc.contributor.author | Trinder, D | en |
dc.contributor.author | Phillips, P A | en |
dc.contributor.author | Casley, David J | en |
dc.contributor.author | Kemp, Bruce E | en |
dc.contributor.author | Mooser, V | en |
dc.contributor.author | Johnston, Colin I | en |
dc.date.accessioned | 2015-05-16T00:49:44Z | |
dc.date.available | 2015-05-16T00:49:44Z | |
dc.date.issued | 1990-07-08 | en |
dc.identifier.citation | Peptides; 11(4): 857-62 | en |
dc.identifier.govdoc | 2146598 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/11240 | en |
dc.description.abstract | The molecular recognition hypothesis, that peptide ligands and their receptor binding sites are encoded by complementary nucleotide sequences, was tested for arginine vasopressin (AVP) and its V1 receptor. Binding of [125I] [d(CH2)5,Sar7]AVP (a selective V1 vasopressin antagonist radioligand) or [3H]AVP to rat liver plasma membranes was inhibited by peptides known to bind to V1 receptors but not by the AVP complementary peptide (Ser-Ser-Trp-Ala-Val-Leu-Glu-Val-Ala) (PVA). Rabbit anti-PVA antibodies were nonimmunoreactive with any protein in rat liver membranes or in a partially purified preparation from rat liver containing reconstitutable vasopressin binding activity. Furthermore, there was no suppression of the AVP pressor effect by PVA in vivo using a rat blood pressure bioassay. These findings do not support the hypothesis that the V1 receptor binding site is encoded by the antisense DNA strand to AVP. | en |
dc.language.iso | en | en |
dc.subject.other | Amino Acid Sequence | en |
dc.subject.other | Animals | en |
dc.subject.other | Cell Membrane.metabolism | en |
dc.subject.other | Immunoblotting | en |
dc.subject.other | Liver.metabolism | en |
dc.subject.other | Molecular Sequence Data | en |
dc.subject.other | Oligopeptides.metabolism | en |
dc.subject.other | Rats | en |
dc.subject.other | Receptors, Angiotensin.isolation & purification.metabolism | en |
dc.subject.other | Receptors, Vasopressin | en |
dc.subject.other | Vasopressins | en |
dc.title | Vasopressin antisense peptide interactions with the V1 receptor. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Peptides | en |
dc.identifier.affiliation | University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 857-62 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/2146598 | en |
dc.type.austin | Journal Article | en |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Journal articles |
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