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|Title:||High-affinity platelet [3H]LSD binding is decreased in panic disorder.|
|Authors:||Norman, Trevor R;Judd, F K;Staikos, V;Burrows, Graham D;McIntyre, I M|
|Affiliation:||Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic., Australia.|
|Citation:||Journal of Affective Disorders; 19(2): 119-23|
|Abstract:||Platelet [3H]LSD binding was measured in 15 patients with panic attacks and 15 controls. The mean (+/- SD) Bmax values of the patients (14.1 +/- 6.3 fmol/mg protein) and of the controls (18.5 +/- 4.7 fmol/mg protein) were significantly different (P less than 0.05, Mann-Whitney U-test). Mean (+/- SD) values of Kd for the patients (0.55 +/- 0.34 nM) and for the controls (0.51 +/- 0.12 nM) were not significantly different (P greater than 0.1, Mann-Whitney U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders.|
|Internal ID Number:||2142698|
Lysergic Acid Diethylamide.pharmacokinetics
|Appears in Collections:||Journal articles|
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