Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11210
Title: Gastrins, iron homeostasis and colorectal cancer.
Authors: Kovac, Suzana;Anderson, Gregory J;Baldwin, Graham S
Affiliation: The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.
Issue Date: 12-Feb-2011
Citation: Biochimica Et Biophysica Acta 2011; 1813(5): 889-95
Abstract: The peptide hormone gastrin has been identified as a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. The importance of gastric acid in the absorption of dietary iron first became evident 50 years ago when iron deficiency anemia was recognized as a long-term consequence of partial gastrectomy. This review summarizes the connections between circulating gastrins, iron status and colorectal cancer. Gastrins bind two ferric ions with micromolar affinity and, in the case of non-amidated forms of the hormone, iron binding is essential for biological activity in vitro and in vivo. The demonstration of an interaction between gastrin and transferrin by biochemical techniques led to the proposal that gastrins catalyze the loading of transferrin with iron. Several lines of evidence, including the facts that the concentrations of circulating gastrins are increased in mice and humans with the iron overload disease hemochromatosis and that transferrin saturation positively correlates with circulating gastrin concentration, suggest the potential involvement of gastrins in iron homeostasis. Conversely, recognition that ferric ions play an unexpected role in the biological activity of gastrins may assist in the development of useful therapies for colorectal carcinoma and other disorders of mucosal proliferation in the gastrointestinal tract. This article is part of a Special Issue entitled: 11th European Symposium on Calcium.
Internal ID Number: 21320535
URI: http://ahro.austin.org.au/austinjspui/handle/1/11210
DOI: 10.1016/j.bbamcr.2011.02.007
URL: http://www.ncbi.nlm.nih.gov/pubmed/21320535
Type: Journal Article
Subjects: Animals
Biological Transport
Colorectal Neoplasms.metabolism
Gastrins.metabolism
Homeostasis
Humans
Iron.metabolism
Receptor, Cholecystokinin B.metabolism
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.