Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11207
Title: Trabecular bone of growth plate origin influences both trabecular and cortical morphology in adulthood.
Authors: Wang, Qingju;Ghasem-Zadeh, Ali;Wang, Xiao-Fang;Iuliano-Burns, Sandra;Seeman, Ego
Affiliation: qingjuw@yahoo.com
Endocrine Centre, Heidelberg Repatriation Hospital, Austin Health, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 1-Jul-2011
Citation: Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research; 26(7): 1577-83
Abstract: Skeletal fragility is common at metaphyseal regions of long bones. The cortices of this region are derived by coalescence of trabeculae around the periphery of the growth plate, not by periosteal apposition, as occurs in the diaphyses. We therefore hypothesized that trabecular bone in childhood predicted both cortical and trabecular morphology in adulthood. To test this hypothesis, we measured distal radial and tibial structure using high-resolution peripheral quantitative computed tomography in 61 daughter-mother pairs, mean age 12.5 years (range 7 to 19 years) and 44.1 years (range 32 to 50 years), respectively. The daughters' trabecular bone volume (BV/TV), thickness, number, and separation predicted the corresponding traits in their mothers. Their trabecular BV/TV also predicted their mothers' cortical thickness (r = 0.32, p = .02). By contrast, the daughters' cortical thickness did not predict their mothers' cortical thickness. The daughters had higher trabecular BV/TV than their mothers (mean ± SD, radius 0.134 ± 0.024 versus 0.124 ± 0.033, p = .03; tibia 0.145 ± 0.021 versus 0.135 ± 0.032, p < .01) owing to greater trabecular number, not thickness, and less trabecular separation. Abnormalities in the development of metaphyseal trabecular bone are likely to influence fragility in both trabecular and cortical bone of this region in adulthood.
Internal ID Number: 21312271
URI: http://ahro.austin.org.au/austinjspui/handle/1/11207
DOI: 10.1002/jbmr.360
URL: http://www.ncbi.nlm.nih.gov/pubmed/21312271
Type: Journal Article
Subjects: Adolescent
Adult
Aging.physiology
Anthropometry
Bone Density.physiology
Child
Female
Growth Plate.anatomy & histology.physiology
Humans
Middle Aged
Mothers
Nuclear Family
Organ Size
Radius.anatomy & histology.physiology
Tibia.anatomy & histology.physiology
Young Adult
Appears in Collections:Journal articles

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