Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11195
Title: Risk of arterial thromboembolic events in patients with advanced colorectal cancer receiving bevacizumab.
Authors: Tebbutt, Niall C;Murphy, F;Zannino, D;Wilson, K;Cummins, M M;Abdi, E;Strickland, A H;Lowenthal, R M;Marx, G;Karapetis, C;Shannon, J;Goldstein, David B;Nayagam, S S;Blum, R;Chantrill, L;Simes, R J;Price, Timothy J
Institutional Author: Australasian Gastro-Intestinal Trials Group
Affiliation: Department of Medical Oncology, Austin Health, Melbourne, Australia. niall.tebbutt@ludwig.edu.au
Issue Date: 27-Jan-2011
Citation: Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo 2011; 22(8): 1834-8
Abstract: Bevacizumab is an antiangiogenic mAb with efficacy against several cancers, but it is associated with risk of arterial thromboembolism (ATE). Further data are needed to determine the safety of bevacizumab.We recorded grade 3, 4, or 5 ATE events and other data (including age, baseline cardiovascular risk factors, history of ATE, and aspirin use) from 471 patients with metastatic colorectal cancer in the MAX (Mitomycin, Avastin, Xeloda) trial of capecitabine monotherapy versus capecitabine with bevacizumab with or without mitomycin C.Bevacizumab-treated patients had 12 grade 3, 4, or 5 ATEs (3.8% incidence). ATEs occurred in 2.1% of patients >65 years, 5% of those with a history of ATE, and 5% of those with cardiac risk factors. Age, history of ATE, or vascular risk factors did not increase risk. Aspirin users had a higher incidence than nonusers (8.9% versus 2.7%) but had higher rates of vascular risk factors.Bevacizumab was associated with a modestly higher risk of ATE, but safety was not significantly worse in older patients or patients with a history of ATE or vascular risk factors. The effect of aspirin in preventing ATE in patients receiving bevacizumab could not be determined from this study.
Internal ID Number: 21273347
URI: http://ahro.austin.org.au/austinjspui/handle/1/11195
DOI: 10.1093/annonc/mdq702
URL: http://www.ncbi.nlm.nih.gov/pubmed/21273347
Type: Journal Article
Subjects: Adult
Age Factors
Aged
Aged, 80 and over
Angiogenesis Inhibitors.adverse effects.therapeutic use
Antibodies, Monoclonal, Humanized.adverse effects.therapeutic use
Aspirin.therapeutic use
Colorectal Neoplasms.drug therapy.pathology
Female
Humans
Male
Middle Aged
Neoplasm Staging
Risk Factors
Thromboembolism.etiology
Appears in Collections:Journal articles

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