Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11185
Title: Progress in the development of preventive and therapeutic vaccines for hepatitis C virus.
Authors: Torresi, Joseph;Johnson, Douglas J;Wedemeyer, Heiner
Affiliation: Austin Centre for Infection Research, Department of Infectious Diseases Austin Hospital, Heidelberg, Victoria 3084, Australia. josepht@unimelb.edu.au
Issue Date: 12-Jan-2011
Citation: Journal of Hepatology 2011; 54(6): 1273-85
Abstract: Hepatitis C virus (HCV) is a blood borne disease estimated to chronically infect 3% of the worlds' population causing significant morbidity and mortality. Current medical therapy is curative in approximately 50% of patients. While recent treatment advances of genotype 1 infection using directly acting antiviral agents (DAAs) are encouraging, there is still a need to develop vaccine strategies capable of preventing infection. Moreover, vaccines may also be used in future in combination with DAAs enabling interferon-free treatment regimens. Viral and host specific factors contribute to viral evasion and present important impediments to vaccine development. Both, innate and adaptive immune responses are of major importance for the control of HCV infection. However, HCV has evolved ways of evading the host's immune response in order to establish persistent infection. For example, HCV inhibits intracellular interferon signalling pathways, impairs the activation of dendritic cells, CD8(+) and CD4(+) T cell responses, induces a state of T-cell exhaustion and selects escape variants with mutations CD8(+) T cell epitopes. An effective vaccine will need to produce strong and broadly cross-reactive CD4(+), CD8(+) T cell and neutralising antibody (NAb) responses to be successful in preventing or clearing HCV. Vaccines in clinical trials now include recombinant proteins, synthetic peptides, virosome based vaccines, tarmogens, modified vaccinia Ankara based vaccines, and DNA based vaccines. Several preclinical vaccine strategies are also under development and include recombinant adenoviral vaccines, virus like particles, and synthetic peptide vaccines. This paper will review the vaccines strategies employed, their success to date and future directions of vaccine design.
Internal ID Number: 21236312
URI: http://ahro.austin.org.au/austinjspui/handle/1/11185
DOI: 10.1016/j.jhep.2010.09.040
URL: http://www.ncbi.nlm.nih.gov/pubmed/21236312
Type: Journal Article
Subjects: Animals
Antibodies, Neutralizing.biosynthesis
Antibodies, Viral.biosynthesis
Clinical Trials as Topic
Epitopes.immunology
Hepacivirus.immunology
Hepatitis C.immunology.prevention & control.therapy
Host-Pathogen Interactions.immunology
Humans
Immunity, Cellular
Models, Immunological
Viral Hepatitis Vaccines.isolation & purification.therapeutic use
Virus Internalization
Appears in Collections:Journal articles

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