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|Title:||The utility of multimodality imaging with CT and MRI in defining rectal tumour volumes for radiotherapy treatment planning: a pilot study.|
|Authors:||Tan, J;Lim Joon, Daryl;Fitt, Gregory J;Wada, Morikatsu;Lim Joon, M;Mercuri, A;Marr, M;Chao, M;Khoo, Vincent|
|Affiliation:||Radiation Oncology Centre, Austin Health, Heidelberg West Radiology, Austin Health, Heidelberg, Victoria 3081, Australia.|
|Citation:||Journal of Medical Imaging and Radiation Oncology; 54(6): 562-8|
|Abstract:||This study compares the volumetric and spatial relationships of gross tumour volume (GTV) derived from CT (CT-GTV) and GTV derived from MRI (MR-GTV) to determine the utility of multi-modality imaging for radiotherapy treatment planning in rectal cancer.Fifteen patients with T3 rectal cancer were accrued over 18 months. The male : female ratio was 2:1. The average age was 60.3 years (range 38-79). All patients underwent a diagnostic MRI and CT and MRI simulation. Data sets were co-registered. A site specialised diagnostic radiologist contoured all volumes in consultation with a radiation oncologist. CT-GTV was contoured while blinded to MR data sets. MR-GTV was contoured independently 2-4 weeks later whilst blinded to its respective CT-GTV data. Tumour volumes were analysed for three anatomical subregions (sigmoid, rectal and anal). Reference points on tumour volumes were used for spatial comparison and analysis.The mean CT-GTV/MR-GTV ratio was 1.2 (range 0.5-2.9). The tumour volume ratios for the rectal subregion were well correlated. CT-GTV provided adequate spatial coverage of tumour in reference to MR-GTV with the average mean discrepancy of 0.12 (range -0.08-0.38) or a maximum discrepancy of <0.4 cm (1.54 standard deviation). CT-GTV coverage was inadequate for tumours with MRI evidence of anal and sigmoid invasion.Conventional simulation CT imaging provided a reasonable estimate of the GTV. Multi-modality imaging with staging MRI can assist target volume definition where there is involvement of the sigmoid and anorectal region and avoid geographic misses. The role of a simulation MRI may aid in this process but remains investigational.|
|Internal ID Number:||21199435|
Contrast Media.diagnostic use
Magnetic Resonance Imaging.methods
Radiotherapy Planning, Computer-Assisted.methods
Tomography, X-Ray Computed.methods
|Appears in Collections:||Journal articles|
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