Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11133
Title: Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor.
Authors: Kovac, Suzana;Xiao, Lin;Shulkes, Arthur;Patel, Oneel;Baldwin, Graham S
Affiliation: The University of Melbourne, Department of Surgery, Austin Health, Heidelberg, Victoria, Australia. kovacs@unimelb.edu.au
Issue Date: 8-Oct-2010
Citation: Febs Letters 2010; 584(21): 4413-8
Abstract: The involvement of the gastrointestinal hormone gastrin in the development of gastrointestinal cancer is highly controversial. Here we demonstrate a positive-feedback loop whereby gastrin, acting via the CCK2 receptor, increases its own expression. Such an autocrine loop has not previously been reported for any other gastrointestinal hormone. Gastrin promoter activation was dependent on the MAP kinase pathway and did not involve Sp1 binding sites or epidermal growth factor receptor transactivation. As the treatment of gastrointestinal cancer cells with amidated gastrin led to increased expression of non-amidated gastrins, the positive-feedback loop may contribute to the sustained increase in circulating gastrins observed in colorectal cancer patients.
Internal ID Number: 20932834
URI: http://ahro.austin.org.au/austinjspui/handle/1/11133
DOI: 10.1016/j.febslet.2010.09.046
URL: http://www.ncbi.nlm.nih.gov/pubmed/20932834
Type: Journal Article
Subjects: Base Sequence
Cell Line, Tumor
Colorectal Neoplasms.blood.genetics.metabolism
Feedback, Physiological
Gastrins.biosynthesis.blood.genetics.metabolism
Gastrointestinal Neoplasms.genetics.metabolism.pathology
Gene Expression Regulation, Neoplastic
Genes, Reporter.genetics
Humans
Luciferases.genetics
MAP Kinase Signaling System
Molecular Sequence Data
Polymerase Chain Reaction
Promoter Regions, Genetic.genetics
Receptor, Cholecystokinin B.metabolism
Time Factors
Transcription, Genetic
Transcriptional Activation
Appears in Collections:Journal articles

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