Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11132
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dc.contributor.authorBahar-Fuchs, Alexen
dc.contributor.authorChételat, Gaelen
dc.contributor.authorVillemagne, Victor Len
dc.contributor.authorMoss, Simonen
dc.contributor.authorPike, Kerryn Een
dc.contributor.authorMasters, Colin Len
dc.contributor.authorRowe, Christopher Cen
dc.contributor.authorSavage, Gregen
dc.date.accessioned2015-05-16T00:43:11Z
dc.date.available2015-05-16T00:43:11Z
dc.date.issued2010en
dc.identifier.citationJournal of Alzheimer's Disease : Jad; 22(4): 1081-7en
dc.identifier.govdoc20930316en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11132en
dc.description.abstractOlfactory deficits and increased amyloid-β (Aβ) burden are observed in people with amnestic mild cognitive impairment (aMCI); both factors may be predictive of Alzheimer's disease (AD). We explored whether olfactory identification is related to in vivo measures of Aβ burden using Pittsburgh Compound B (PiB) PET. Nineteen control, 24 aMCI, and 20 AD participants completed an olfactory identification task and underwent PiB PET scanning. Control participants performed better on olfactory identification and showed lower PiB binding than aMCI patients. There was a significant correlation between both factors when pooling all groups together but not when considering each group separately. In addition, the olfactory identification score did not differ between aMCI participants who were PiB-positive and those who were PiB-negative. We conclude that AD-related olfactory identification deficits are not directly related to Aβ burden.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAging.metabolismen
dc.subject.otherAlzheimer Disease.complications.metabolism.radionuclide imagingen
dc.subject.otherAmyloid beta-Peptides.metabolismen
dc.subject.otherAniline Compoundsen
dc.subject.otherBrain.metabolism.radionuclide imagingen
dc.subject.otherBrain Mappingen
dc.subject.otherCognition Disorders.complications.metabolism.radionuclide imagingen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNeuropsychological Testsen
dc.subject.otherOlfaction Disorders.complications.metabolism.radionuclide imagingen
dc.subject.otherOlfactory Perceptionen
dc.subject.otherThiazolesen
dc.titleOlfactory deficits and amyloid-β burden in Alzheimer's disease, mild cognitive impairment, and healthy aging: a PiB PET study.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Alzheimer's disease : JADen
dc.identifier.affiliationbfalex@gmail.comen
dc.identifier.affiliationDepartment of Nuclear Medicine & Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.3233/JAD-2010-100696en
dc.description.pages1081-7en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20930316en
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