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Title: [125I][D-Tyr25,Nle28,31]CCK-(25-33): a convenient new aminopeptidase resistant cholecystokinin analogue for radioligand binding and autoradiography.
Authors: Carlberg, M;Beart, P M;Jarrott, B
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 20-Nov-1990
Citation: European Journal of Pharmacology; 191(1): 107-10
Abstract: The 125I-labeled sulfated cholecystokinin (CCK) analogue, [D-Tyr25,Nle28,31]CCK-(25-33), bound saturably to membranes from rat cerebral cortex and to brain tissue sections. Competition studies suggested binding to sites of the CCKB subtypes. The high affinity for brain membranes (Kd = 0.14 nM) and high specific binding to brain sections (80-90% specific binding), as well as its high specific radioactivity, makes it a suitable ligand for autoradiographic studies of cholecystokinin receptors.
Internal ID Number: 2092997
Type: Journal Article
Subjects: Aminopeptidases.metabolism
Cholecystokinin.analogs & derivatives.metabolism
In Vitro Techniques
Peptide Fragments.metabolism
Radioligand Assay
Rats, Inbred Strains
Receptors, Cholecystokinin.metabolism
Appears in Collections:Journal articles

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