Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11116
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dc.contributor.authorTurner, Andrew Gen
dc.contributor.authorTjahyono, Franciscaen
dc.contributor.authorChiu, W S Mariaen
dc.contributor.authorSkinner, Jarroden
dc.contributor.authorSawyer, Rebeccaen
dc.contributor.authorMoore, Alison Jen
dc.contributor.authorMorris, Howard Aen
dc.contributor.authorFindlay, David Men
dc.contributor.authorZajac, Jeffrey Den
dc.contributor.authorDavey, Rachel Aen
dc.date.accessioned2015-05-16T00:42:13Z
dc.date.available2015-05-16T00:42:13Z
dc.date.issued2010-09-17en
dc.identifier.citationBone 2010; 48(2): 354-61en
dc.identifier.govdoc20850575en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11116en
dc.description.abstractDespite the therapeutic value of calcitonin in treating bone disease, a biological role of endogenous calcitonin is controversial. Having previously demonstrated that the CTR has a biological role in protecting against calcium stress using a global CTRKO mouse model, the purpose of this study was to determine whether the protection conferred by the CTR during induced hypercalcemia is mediated via CTR expression on osteoclasts. Mice were generated, in which the CTR was deleted specifically within osteoclasts (OCL-CTRKOs) and compared with mice in which the CTR was deleted globally (global CTRKOs). Significantly, peak serum calcium levels following induced hypercalcemia were >18% higher in global-CTRKOs and OCL-CTRKOs than controls (P<0.01) due to increased bone resorption (P<0.05). Peak serum calcium levels relative to controls were greater in global-CTRKO males than OCL-CTRKO males (P<0.001), which may, at least in part, be due to increased reabsorption of calcium in the kidney (P<0.01). Controls for all analyses were sex-matched littermates with normal CTR expression. In conclusion, the CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBone Resorption.genetics.metabolismen
dc.subject.otherCalcitriol.pharmacologyen
dc.subject.otherCalcium.metabolismen
dc.subject.otherFemaleen
dc.subject.otherGenotypeen
dc.subject.otherHypercalcemia.chemically induced.genetics.prevention & controlen
dc.subject.otherMaleen
dc.subject.otherMiceen
dc.subject.otherMice, Knockouten
dc.subject.otherMice, Transgenicen
dc.subject.otherOsteoclasts.metabolismen
dc.subject.otherPolymerase Chain Reactionen
dc.subject.otherReceptors, Calcitonin.genetics.metabolismen
dc.titleThe role of the calcitonin receptor in protecting against induced hypercalcemia is mediated via its actions in osteoclasts to inhibit bone resorption.en
dc.typeJournal Articleen
dc.identifier.journaltitleBoneen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.bone.2010.09.013en
dc.description.pages354-61en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20850575en
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