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|Title:||The core network in absence epilepsy. Differences in cortical and thalamic BOLD response.|
|Authors:||Carney, Patrick W;Masterton, Richard A J;Harvey, A Simon;Scheffer, Ingrid E;Berkovic, Samuel F;Jackson, Graeme D|
|Affiliation:||Brain Research Institute, Florey Neurosciences Institutes, Neurosciences Building, Heidelberg Repatriation Hospital, Austin Health, West Heidelberg, Victoria 3081, Australia|
|Citation:||Neurology 2010; 75(10): 904-11|
|Abstract:||We used EEG-fMRI to study epileptiform activity in a cohort of untreated children with typical absence seizures (AS). Our aim was to identify cortical and subcortical regions involved in spike and wave events and to explore the timing of activity in these regions.Eleven children with AS confirmed on video-EEG underwent EEG-fMRI. An event-related analysis of epileptiform activity was performed. Regions of interest (ROIs), identified in the event-related analysis, were used to study the time course of the blood oxygen level-dependent (BOLD) signal prior to and immediately following events of interest in these ROIs.Group analysis confirmed positive BOLD in the thalamus and negative BOLD in the lateral and mesial parietal lobe, caudate nuclei, and additionally the brainstem reticular formation. The event-related time course differed between the thalamus, the parietal cortex, and the pons and caudate nuclei. In the subcortical structures, BOLD signal change occurred at, or immediately after, electrographic onset. Importantly, in the parietal cortex, but not in other cortical regions, there was a subtle BOLD signal increase for 10 seconds prior to the onset of epileptiform activity.In children with typical AS, we have confirmed a core network of structures involved in generalized epileptiform activity that includes the reticular structures of the brainstem. Furthermore, we have identified changes in parietal BOLD signal which precede the onset of epileptiform activity, suggesting the parietal cortex has a role in the initiation of epileptiform activity.|
|Internal ID Number:||20702791|
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Signal Processing, Computer-Assisted
|Appears in Collections:||Journal articles|
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