Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11071
Title: Production of calcitonin gene related peptide, calcitonin and PTH-related protein by a prostatic adenocarcinoma.
Authors: Shulkes, Arthur;Fletcher, D R;Rubinstein, C;Ebeling, Peter R;Martin, T J
Affiliation: University of Melbourne, Department of Surgery, Austin Hospital, Melbourne, Victoria, Australia.
Issue Date: 1-May-1991
Citation: Clinical Endocrinology; 34(5): 387-93
Abstract: PTH and calcitonin are the two major hormones controlling calcium metabolism. Recently two new substances related to these hormones have been isolated: calcitonin gene related peptide (CGRP) and PTH-related protein (PTHrP). CGRP is a potent vasodilator and stimulant of intestinal secretion while PTHrP is probably the agent responsible for humoral hypercalcaemia of malignancy. We report here a patient with a prostatic tumour presenting with vasodilation, diarrhoea and hypercalcaemia. Our investigations revealed that the primary prostatic and liver secondary tumour contained CGRP, calcitonin and PTHrP. Most of the immunoreactive CGRP in the tumour and plasma co-eluted with the biologically active form of CGRP. The circulating levels of CGRP correlated with the presence of the diarrhoea. PTHrP concentration in the tumours was one of the highest reported for any tumour although previous studies may have utilized less than optimal extraction procedures. The somatostatin analogue, octreotide (SMS 201-995), did not reduce the plasma CGRP or the diarrhoea, a finding similar to that seen in patients with medullary thyroid carcinoma and high plasma CGRP. The hypercalcaemia was also unaffected by octreotide administration. This is the first report of a prostatic tumour associated with over-production of calcitonin, PTHrP and CGRP. The major life-threatening effects of this unusual case of prostatic carcinoma were diarrhoea and hypercalcaemia. Both these effects could be tentatively ascribed to newly discovered substances, CGRP and PTHrP. With the greater availability of assays to measure CGRP and PTHrP in plasma, a detailed examination of the incidence of over-production of these substances in various cancers will be possible.
Internal ID Number: 2060148
URI: http://ahro.austin.org.au/austinjspui/handle/1/11071
URL: http://www.ncbi.nlm.nih.gov/pubmed/2060148
Type: Journal Article
Subjects: Adenocarcinoma.complications.metabolism.secondary
Calcitonin.biosynthesis
Calcitonin Gene-Related Peptide.biosynthesis
Chromatography, High Pressure Liquid
Diarrhea.etiology
Humans
Hypercalcemia.etiology
Liver Neoplasms.secondary
Male
Middle Aged
Neoplasm Proteins.biosynthesis
Parathyroid Hormone-Related Protein
Prostatic Neoplasms.complications.metabolism
Protein Biosynthesis
Radioimmunoassay.methods
Appears in Collections:Journal articles

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