Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11050
Title: Evaluation of cellular immune responses in cancer vaccine recipients: lessons from NY-ESO-1.
Authors: Cebon, Jonathan S;Knights, Ashley J;Ebert, Lisa;Jackson, Heather M;Chen, Weisan
Affiliation: Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg VIC 3084, Australia.
Issue Date: 1-Jun-2010
Citation: Expert Review of Vaccines; 9(6): 617-29
Abstract: The rigorous evaluation of cancer vaccination requires evidence of benefit to patients with cancer or those at risk of relapse from the disease. Clinical trials are expensive and require considerable human and clinical resources in order to demonstrate this benefit. In the era of defined cancer antigens, it is possible to evaluate immunogenic targets, and assess the quality and magnitude of immune responses against these antigens following vaccination. Analyzing these surrogate end points complements clinical assessment and provides a depth of understanding to better inform trial evaluation and design. We have used the immunogenic cancer testis antigen NY-ESO-1 as a model antigen. This article summarizes our experience in monitoring immunity against NY-ESO-1.
Internal ID Number: 20518717
URI: http://ahro.austin.org.au/austinjspui/handle/1/11050
DOI: 10.1586/erv.10.58
URL: http://www.ncbi.nlm.nih.gov/pubmed/20518717
Type: Journal Article
Subjects: Antigens, Neoplasm.immunology
CD4-Positive T-Lymphocytes.immunology
CD8-Positive T-Lymphocytes.immunology
Cancer Vaccines.immunology
Humans
Interferon-gamma.biosynthesis
Membrane Proteins.immunology
Neoplasms.immunology.therapy
Skin Tests
T-Lymphocytes.immunology
T-Lymphocytes, Regulatory.immunology
Appears in Collections:Journal articles

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