Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11046
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dc.contributor.authorConway, Elizabeth Len
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T00:37:29Z
dc.date.available2015-05-16T00:37:29Z
dc.date.issued1988-05-16en
dc.identifier.citationNeurochemistry International; 12(3): 315-22en
dc.identifier.govdoc20501234en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11046en
dc.description.abstractNoradrenaline and noradrenaline turnover were determined in regions enriched in catecholamine nuclei of the brainstem (A1, A2, C1, C2 and C3), in the locus coeruleus (A6) and in the nucleus tractus spinalis n. trigemini (Sp5C) of Wistar Kyoto and spontaneously hypertensive rats at four ages from 6 to 40 weeks. Adrenaline levels were also determined but were only consistently detected in the C1 and C2 regions. There was an age-related decline in noradrenaline concentrations in both strains of rats in all brainstem catecholamine nuclei however noradrenaline turnover decreased only in the A2 and C3 regions and this may contribute to the progressive rise in blood pressure with age in spontaneously hypertensive and Wistar Kyoto rats. Adrenaline levels did not alter with age providing evidence of a functional disassociation between adrenaline and noradrenaline neuronal systems. There were several strain-related differences in noradrenaline and adrenaline concentrations in the regions studied, however noradrenaline turnover was reduced only in the A2 and C2 regions (nucleus tractus solitarius) of spontaneously hypertensive rats which is consistent with the sympathoinhibitory role of this nucleus in central blood pressure regulation.en
dc.language.isoenen
dc.titleAge related changes in noradrenaline, noradrenaline turnover and adrenaline in brainstem nuclei of wistar kyoto and spontaneously hypertensive rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurochemistry internationalen
dc.identifier.affiliationClinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Hospital, Heidelberg, Victoria, 3084, Australiaen
dc.description.pages315-22en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20501234en
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