Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11040
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dc.contributor.authorLewis, S Jen
dc.contributor.authorFennessy, M Ren
dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorJarrott, Ben
dc.contributor.authorTaylor, D Aen
dc.date.accessioned2015-05-16T00:37:08Z
dc.date.available2015-05-16T00:37:08Z
dc.date.issued1986-05-16en
dc.identifier.citationNeurochemistry International; 9(1): 99-102en
dc.identifier.govdoc20493106en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11040en
dc.description.abstractThe effects of intravenous administration of ?(9)-tetrahydrocannabinol (?(9)-THC, 2 mg/kg, i.v.) on the regional brain spermidine concentrations of the rat were examined. Thirty minutes after vehicle treatment, the spermidine concentrations were: for the medulla oblongata/pons, 68.2 +/- 7.7 ?g/g; the hypothalamus, 67.7 +/- 2.6 ?g/g; the midbrain, 59.1 +/- 4.4 ?g/g; the cerebellum, 47.3 +/- 5.9 ?g/g and for the cortex, 13.8 +/- 0.8 ?g/g. Thirty minutes after ?(9)-THC, these concentrations were reduced in the midbrain (47.0 +/- 8.0% of control, P < 0.0001) and cortex (69.4 +/- 7.4% of control, P < 0.009). The spermidine concentrations were not significantly altered in the medulla oblongata/pons (86.5 +/- 13.3%, P > 0.36), hypothalamus (107.2 +/- 11.8, P > 0.36) or cerebellum (89.0 +/- 14.4%, P < 0.48). These results suggest that spermidine within the midbrain and cortex may be involved in the expression of some of the actions of ?(9)-THC.en
dc.language.isoenen
dc.titleThe effects of ?(9)-tetrahydrocannabinol ?(9)-THC) on the regional concentrations of spermidine in the rat brain.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurochemistry internationalen
dc.identifier.affiliationDepartment of Medicine, Clinical Pharmacology Therapeutics Unit, University of Melbourne, Austin Hospital, Heidelberg, Victoria, 3084, Australiaen
dc.description.pages99-102en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20493106en
dc.type.austinJournal Articleen
local.name.researcherVerberne, Anthony J M
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
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