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Title: Impact of chronic kidney disease on patient outcome following cardiac surgery.
Authors: Hedley, Adam J;Roberts, Matthew A;Hayward, Philip A R;Shaw, Margaret;Matalanis, George;Buxton, Brian F;Farouque, Omar;Ierino, Francesco L
Affiliation: Department of Nephrology, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia
Issue Date: 24-Apr-2010
Citation: Heart, Lung & Circulation 2010; 19(8): 453-9
Abstract: Renal impairment is a major risk factor for cardiovascular disease. This study addressed clinical predictors of outcome following cardiac surgery, focusing on pre-operative renal dysfunction.All patients undergoing cardiac surgery at Austin Health from June 1, 2001 to June 30, 2006, were included in the analysis. Logistic regression models were used to evaluate clinical factors predicting "operative mortality" and common post-operative complications.The operative mortality was 1.36% for coronary artery bypass grafting (CABG) alone (n=1027), 5.07% for valve surgery alone (n=217), 4.43% for combined CABG and valve surgery (n=158) and 11.11% for other cardiac surgical procedures (n=270). Amongst CABG alone patients, pre-operative renal impairment was a strong predictor of operative mortality, with a 35-43% increased risk of death (p=0.005) for every 10 ml/min/1.73 m(2) that the glomerular filtration rate was lower. Peripheral vascular disease, recent myocardial infarction and congestive cardiac failure also predicted operative mortality. Pre-operative renal impairment also increased the rate of various post-operative complications, as well as duration of admission.Renal dysfunction is significantly associated with increased mortality and morbidity following cardiac surgery and necessitates careful consideration in risk benefit analysis when considering cardiac surgery.
Internal ID Number: 20418160
DOI: 10.1016/j.hlc.2010.03.005
Type: Journal Article
Subjects: Aged
Confidence Intervals
Coronary Artery Bypass.adverse effects.mortality
Databases, Factual
Heart Failure
Heart Valve Prosthesis.adverse effects.statistics & numerical data
Kidney Failure, Chronic.complications
Middle Aged
Multivariate Analysis
Myocardial Infarction
Odds Ratio
Peripheral Vascular Diseases
Renal Replacement Therapy
Retrospective Studies
Treatment Outcome
Appears in Collections:Journal articles

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