Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11018
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dc.contributor.authorPorritt, Michelle Jen
dc.contributor.authorChen, Michelleen
dc.contributor.authorRewell, Sarah S Jen
dc.contributor.authorDean, Rachael Gen
dc.contributor.authorBurrell, Louise Men
dc.contributor.authorHowells, David Williamen
dc.date.accessioned2015-05-16T00:35:49Z
dc.date.available2015-05-16T00:35:49Z
dc.date.issued2010-04-21en
dc.identifier.citationJournal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2010; 30(8): 1520-6en
dc.identifier.govdoc20407464en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11018en
dc.description.abstractAngiotensin-converting enzyme (ACE) inhibition can reduce stroke risk by up to 43% in humans and reduce the associated disability, and hence understanding the mechanism of improvement is important. In animals and humans, these effects may be independent of the blood pressure-lowering effects of ACE inhibition. Normotensive (Wistar-Kyoto (WKY)) and hypertensive (spontaneously hypertensive rat (SHR)) animals were treated with the ACE inhibitors ramipril or lisinopril for 7 or 42 days before 2 hours of transient middle cerebral artery occlusion (MCAo). Blood pressure, serum ACE, and blood glucose levels were measured and stroke infarct volume was recorded 24 hours after stroke. Despite greater reductions in blood pressure, infarct size was not improved by ACE inhibition in hypertensive animals. Short-term ACE inhibition produced only a modest reduction in blood pressure, but WKY rats showed marked reductions in infarct volume. Long-term ACE inhibition had additional reductions in blood pressure; however, infarct volumes in WKY rats did not improve further but worsened. WKY rats differed from SHR in having marked cortical ACE activity that was highly sensitive to ACE inhibition. The beneficial effects of ACE inhibition on infarct volume in normotensive rats do not correlate with changes in blood pressure. However, WKY rats have ACE inhibitor-sensitive cortical ACE activity that is lacking in the SHR.en
dc.language.isoenen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.therapeutic useen
dc.subject.otherAnimalsen
dc.subject.otherCerebral Cortex.drug effects.enzymologyen
dc.subject.otherHypertension.drug therapy.enzymologyen
dc.subject.otherInfarction, Middle Cerebral Artery.drug therapy.enzymologyen
dc.subject.otherLisinopril.therapeutic useen
dc.subject.otherMaleen
dc.subject.otherPeptidyl-Dipeptidase A.metabolismen
dc.subject.otherRamipril.therapeutic useen
dc.subject.otherRatsen
dc.subject.otherRats, Wistaren
dc.titleACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activity.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolismen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia en
dc.identifier.doi10.1038/jcbfm.2010.57en
dc.description.pages1520-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20407464en
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
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