Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11001
Title: Can changes in cortical excitability distinguish progressive from juvenile myoclonic epilepsy?
Authors: Badawy, Radwa A B;Macdonell, Richard A L;Jackson, Graeme D;Berkovic, Samuel F
Affiliation: Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.
Issue Date: 1-Oct-2010
Citation: Epilepsia; 51(10): 2084-8
Abstract: We used transcranial magnetic stimulation (TMS) to investigate whether there were any characteristic cortical excitability changes in progressive myoclonic epilepsy (PME) compared to juvenile myoclonic epilepsy (JME).Six patients with PME were studied. Motor threshold (MT) at rest and recovery curve analysis using paired-pulse stimulation at a number of interstimulus intervals (ISIs) was determined. Results were compared to those of 9 patients with chronic refractory JME and 10 with chronic well-controlled JME.PME showed a marked increase in cortical excitability at all the long ISIs (p < 0.01), compared to refractory JME (effect sizes ranging from 1.4 to 1.9) and well-controlled JME (effect sizes ranging from 2.0 to 2.4). Significant differences at the short ISIs 2-5 ms were seen only on comparison with the well-controlled group (p < 0.05, effect size 0.6, 0.7). There were no significant differences in MTs of PME compared to either JME groups.Our findings demonstrate specific differences in cortical excitability using TMS between PME and those with JME, particularly at long latencies in the paired-pulse paradigm, implicating a role for γ-aminobutyric acid (GABA)(B) -mediated networks.
Internal ID Number: 20384725
URI: http://ahro.austin.org.au/austinjspui/handle/1/11001
DOI: 10.1111/j.1528-1167.2010.02557.x
URL: http://www.ncbi.nlm.nih.gov/pubmed/20384725
Type: Journal Article
Subjects: Adult
Anticonvulsants.therapeutic use
Cerebral Cortex.physiopathology
Chronic Disease
Diagnosis, Differential
Drug Resistance
Female
Humans
Male
Middle Aged
Motor Cortex.physiopathology
Myoclonic Epilepsies, Progressive.diagnosis.drug therapy.physiopathology
Myoclonic Epilepsy, Juvenile.diagnosis.drug therapy.physiopathology
Transcranial Magnetic Stimulation.methods.statistics & numerical data
Unverricht-Lundborg Syndrome.diagnosis.physiopathology
gamma-Aminobutyric Acid.physiology
Appears in Collections:Journal articles

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