Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10997
Title: Renal plasma flow and glomerular filtration rate during acute kidney injury in man.
Authors: Prowle, John R;Ishikawa, Ken;May, Clive N;Bellomo, Rinaldo
Affiliation: Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Jan-2010
Citation: Renal Failure; 32(3): 349-55
Abstract: During acute kidney injury (AKI), lowered glomerular filtration rate (GFR) is believed to be consequent to reduced renal plasma flow (RPF). We aimed to systematically evaluate the evidence for such an association. Using specific search terms, we systematically interrogated the Pub Med electronic reference database for studies of human AKI where renal plasma or blood flow and GFR were measured; older articles were then identified by screening bibliographies of retrieved reports. We identified 22 articles describing 250 patients (203 native kidney, 47 in renal allograft). Of these studies, 8 articles (110 patients) estimated effective renal plasma flow (ERPF) by clearance techniques and 14 articles (140 patients) estimated true renal plasma flow (TRPF). Mean RPF was 272 mL/min (95% CI 213-331) and GFR 13.9 mL/min (9.9-17.9). Mean TRPF was significantly greater than mean ERPF (344 vs. 180, p=0.004) despite lower mean GFR (8.8 vs. 20.4, p=0.002). There was no significant association between RPF and GFR between studies. Eleven studies presented individual patient data (76 patients: 49 TRPF, 27 ERPF); here, individual patient ERPF was associated with GFR (r2=0.52), but TRPF was not. During AKI in man, there is only a limited association between ERPF and GFR, and no detectable association between TRPF and GFR.
Internal ID Number: 20370451
URI: http://ahro.austin.org.au/austinjspui/handle/1/10997
DOI: 10.3109/08860221003611695
URL: http://www.ncbi.nlm.nih.gov/pubmed/20370451
Type: Journal Article
Subjects: Acute Kidney Injury.physiopathology
Glomerular Filtration Rate
Humans
Renal Circulation
Renal Plasma Flow
Appears in Collections:Journal articles

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