Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10990
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dc.contributor.authorMussa, Bashair Men
dc.contributor.authorSartor, Daniela Men
dc.contributor.authorVerberne, Anthony J Men
dc.date.accessioned2015-05-16T00:34:09Z
dc.date.available2015-05-16T00:34:09Z
dc.date.issued2010-03-26en
dc.identifier.citationAutonomic Neuroscience : Basic & Clinical 2010; 156(1-2): 36-43en
dc.identifier.govdoc20346737en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10990en
dc.description.abstractThe dorsal motor nucleus of the vagus (DMV) is the main source of the vagal innervation of the pancreas. Several studies in vitro have demonstrated that the DMV consists of a heterogeneous population of preganglionic neurons but little is known about their electrophysiological characteristics in vivo. The aims of this study were to (i) identify DMV preganglionic neurons in vivo with axons in the pancreatic vagus and (ii) characterize their responses to stimulation of cholecystokinin (CCK(1)) and serotonin (5-HT(3)) receptors which are major regulators of pancreatic secretion. Male Sprague Dawley rats anaesthetised with isoflurane (1.5%/100% O(2)) were used throughout. Dorsal vagal preganglionic neurons were identified by antidromic activation in response to stimulation of the pancreatic vagus. Dorsal vagal preganglionic neurons had axonal conduction velocities in the C-fibre range (0.7+/-0.03 m/s). Forty-four neurons were identified within the rostral, intermediate and caudal DMV and thirty-eight were tested for responsiveness to CCK-8S (CCK(1) agonist) and phenylbiguanide (PBG; 5-HT(3) receptor agonist). CCK-8S and PBG (0.1-10 microg/kg, i.v.) produced three types of response: (i) preganglionic neurons in the intermediate DMV were inhibited by CCK-8S (n=18) and PBG (n=10), (ii) neurons in the caudal DMV were activated by CCK (n=5) and PBG (n=2) and (iii) CCK-8S (n=9) and PBG (n=7) had no effect on preganglionic neurons in the rostral DMV. CCK-8S and PBG have complex actions on preganglionic neurons in the DMV that may be related to their effects on pancreatic secretion.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAutonomic Fibers, Preganglionic.drug effects.physiologyen
dc.subject.otherChemokines, CC.agonists.physiologyen
dc.subject.otherElectric Stimulation.methodsen
dc.subject.otherMaleen
dc.subject.otherNeural Inhibition.drug effects.physiologyen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherReceptors, Serotonin, 5-HT3.physiologyen
dc.subject.otherSerotonin 5-HT3 Receptor Agonists.pharmacologyen
dc.subject.otherSincalide.analogs & derivatives.pharmacologyen
dc.subject.otherVagus Nerve.physiologyen
dc.titleDorsal vagal preganglionic neurons: differential responses to CCK1 and 5-HT3 receptor stimulation.en
dc.typeJournal Articleen
dc.identifier.journaltitleAutonomic neuroscience : basic & clinicalen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin Health, Heidelberg 3084, Victoria, Australiaen
dc.identifier.doi10.1016/j.autneu.2010.03.001en
dc.description.pages36-43en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20346737en
dc.type.austinJournal Articleen
local.name.researcherVerberne, Anthony J M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
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