Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10964
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dc.contributor.authorMasterton, Richard A J-
dc.contributor.authorHarvey, A Simon-
dc.contributor.authorArcher, John S-
dc.contributor.authorLillywhite, Leasha M-
dc.contributor.authorAbbott, David F-
dc.contributor.authorScheffer, Ingrid E-
dc.contributor.authorJackson, Graeme D-
dc.date.accessioned2015-05-16T00:32:32Z
dc.date.available2015-05-16T00:32:32Z
dc.date.issued2010-02-06-
dc.identifier.citationNeuroimage 2010; 51(1): 252-60en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10964en
dc.description.abstractSimultaneous EEG and functional MRI (EEG-fMRI) studies of focal epileptiform spikes commonly use the canonical haemodynamic response function (HRF) to model the blood-oxygenation-level-dependent (BOLD) response to these events. Support for the use of the canonical HRF has come from large studies that contain mixed cohorts of epilepsy syndromes and discharge types, and has demonstrated plausible epileptic localisation results in the majority of patients. Other studies, however, have reported that some patients show a BOLD response that differs markedly from a canonical HRF. Our aim in this study was to see if the BOLD response is well modelled by a canonical HRF in a homogeneous cohort of patients with benign epilepsy with centrotemporal spikes (BECTS), an idiopathic partial epilepsy with stereotypical centrotemporal spikes on the EEG. We studied eight well-characterised and typical BECTS patients and found that the shape of the average BOLD response was different to the canonical HRF. Furthermore, a localisation analysis using the group-average response provided increased sensitivity and specificity compared to the canonical HRF. Our findings suggest that the canonical HRF may not provide the best model for the BOLD response in some epilepsy syndromes or spike-types. In studies of homogeneous patient groups, therefore, localisation results may be improved by using a group-specific BOLD response.en_US
dc.language.isoenen
dc.subject.otherBrain.blood supply.physiopathologyen
dc.subject.otherBrain Mapping.methodsen
dc.subject.otherCerebrovascular Circulation.physiologyen
dc.subject.otherChilden
dc.subject.otherChild, Preschoolen
dc.subject.otherCohort Studiesen
dc.subject.otherElectroencephalography.methodsen
dc.subject.otherEpilepsy, Rolandic.diagnosis.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherMaleen
dc.subject.otherModels, Neurologicalen
dc.subject.otherOxygen.blooden
dc.subject.otherSensitivity and Specificityen
dc.subject.otherSignal Processing, Computer-Assisteden
dc.subject.otherTime Factorsen
dc.titleFocal epileptiform spikes do not show a canonical BOLD response in patients with benign rolandic epilepsy (BECTS).en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNeuroImageen_US
dc.identifier.affiliationBrain Research Institute, Florey Neuroscience Institutes, (Austin), Melbourne, Australiaen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.doi10.1016/j.neuroimage.2010.01.109en_US
dc.description.pages252-60en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20139011en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAbbott, David F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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