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|Title:||Inducing stroke in aged, hypertensive, diabetic rats.|
|Authors:||Rewell, Sarah S J;Fernandez, John A;Cox, Susan F;Spratt, Neil J;Hogan, Lisa;Aleksoska, Elena;van Raay, Leena;Liberatore, Gabriel T;Batchelor, Peter Egerton;Howells, David William|
|Affiliation:||National Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Heidelberg, Victoria, Australia.|
|Citation:||Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2010; 30(4): 729-33|
|Abstract:||Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2 h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.|
|Internal ID Number:||20068574|
Diabetes Mellitus, Experimental.epidemiology.physiopathology
Disease Models, Animal
Rats, Inbred SHR
|Appears in Collections:||Journal articles|
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