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Title: High impact of 18F-FDG-PET on management and prognostic stratification of newly diagnosed small cell lung cancer.
Authors: Azad, Arun A;Chionh, Fiona;Scott, Andrew M;Lee, Szeting T;Berlangieri, Salvatore U;White, Shane C;Mitchell, Paul L R
Ludwig Institute Oncology Unit, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 17-Nov-2009
Citation: Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging 2009; 12(4): 443-51
Abstract: We evaluated whether 18F-FDG-PET altered stage classification, management, and prognostic stratification of newly diagnosed small cell lung cancer (SCLC).We identified 46 consecutive patients undergoing staging positron emission tomography for SCLC from 1993-2008 inclusive. Updated survival data from the state Cancer Registry was available on 42 of 46 patients.PET altered stage classification in 12 of 46 (26%) patients. PET altered treatment modality in nine patients, and the target mediastinal radiation field in another three patients. Therefore, PET altered management in 12 of 46 (26%) patients. Patients with limited disease (LD) on pre-PET staging had significantly longer overall survival (OS) than those upstaged to extensive disease (ED; median 18.6 months versus 5.7 months; log-rank p < 0.0001). In patients with ED on pre-PET staging, those downstaged to LD by PET had significantly longer OS than those with ED on PET (median 10.9 months versus 5.9 months; log-rank p = 0.037).PET had a major impact on stage classification, management, and prognostic stratification of newly diagnosed SCLC.
Internal ID Number: 19921339
DOI: 10.1007/s11307-009-0295-z
Type: Journal Article
Subjects: Aged
Fluorodeoxyglucose F18.diagnostic use
Kaplan-Meier Estimate
Lung Neoplasms.pathology.radiography.radionuclide imaging.therapy
Neoplasm Staging
Positron-Emission Tomography
Proportional Hazards Models
Small Cell Lung Carcinoma.pathology.radiography.radionuclide imaging.therapy
Tomography, X-Ray Computed
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