Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10913
Title: Bone modeling and remodeling.
Authors: Seeman, Ego
Affiliation: Department of Endocrinology, Repatriation Campus, Austin Health, Melbourne, Australia. egos@unimelb.edu.au
Issue Date: 2009
Citation: Critical Reviews in Eukaryotic Gene Expression; 19(3): 219-33
Abstract: Bone modeling adapts structure to loading by changing bone size and shape and removes damage and so maintains bone strength. Remodeling is initiated by damage producing osteocyte apoptosis, which signals the location of damage via the osteocyte-canalicular system to endosteal lining cells that form the canopy of a bone remodeling compartment (BRC). Molecular signalling within the BRC between precursors, mature cells, cells of the immune system, and products of the resorbed matrix titrate the birth, work, and lifespan of this remodeling machinery to either remove or form a net volume of bone. Advancing age is associated with a reduction in the volume of bone resorbed by each basic multicellular unit (BMU), an even greater reduction in the volume of bone formed by each BMU producing a net negative BMU balance, and an increased remodeling rate in midlife in women and late in life in both sexes so that now many remodeling events erode bone while an age-related decline in periosteal apposition results in net bone loss and bone fragility. A better understanding of the mechanisms responsible for structural decay is likely to reveal new approaches to the prevention and reversal of bone fragility.
Internal ID Number: 19883366
URI: http://ahro.austin.org.au/austinjspui/handle/1/10913
URL: http://www.ncbi.nlm.nih.gov/pubmed/19883366
Type: Journal Article
Subjects: Age Factors
Animals
Bone Density.physiology
Bone Remodeling.physiology
Bone Resorption.pathology
Bone and Bones.physiology
Female
Humans
Mechanotransduction, Cellular.physiology
Osteoblasts.physiology
Osteocytes.physiology
Osteogenesis.physiology
Osteoporosis.pathology
Sex Factors
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.