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Title: Dexamethasone-induced flares of Trichophyton rubrum masquerading as docetaxel cutaneous toxicity: a case report.
Authors: Azad, Arun A;Kaufman, Melissa;Jayarajan, Jyotsna
Affiliation: Ludwig Institute for Cancer Research, University of Melbourne, Austin Hospital, Austin Health, 145-163 Studley Road, Heidelberg, Victoria, Australia, 3084.
Issue Date: 23-Jul-2009
Citation: Cases Journal 2009; 2(): 8552
Abstract: Docetaxel chemotherapy is increasingly used in the treatment of castration-resistant prostate cancer. Cutaneous toxicity is common with docetaxel, occurring in up to 75% of cases. We present an unusual case of castration-resistant prostate cancer in which our patient developed recurrent but transient episodes of skin rash following each cycle of docetaxel. Initially, the rash was attributed to docetaxel cutaneous toxicity however a microbiological diagnosis of Trichophyton rubrum was subsequently made. We postulated that dexamethasone pre-medication transiently suppressed anti-fungal immunity, and indeed further flares were prevented by significantly reducing the dose of dexamethasone while continuing treatment with docetaxel.
Internal ID Number: 19830081
DOI: 10.4076/1757-1626-2-8552
Type: Journal Article
Appears in Collections:Journal articles

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