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|Title:||Chronic administration of MK-801 and the NMDA receptor: further evidence for reduced sensitivity of the primary acceptor site from studies with the cortical wedge preparation.|
|Authors:||Beart, P M;Lodge, D|
|Affiliation:||University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia|
|Citation:||The Journal of Pharmacy and Pharmacology; 42(5): 354-5|
|Abstract:||Cortical slices removed from rats pre-treated with MK-901 0.5 mg kg-1 twice a day for 7 days had reduced responses to N-methyl-D-aspartate (NMDA) relative to quisqualate and glutamate compared with control animals. Potencies of competitive (CPMP) and non-competitive (ketamine) NMDA antagonists appeared unchanged. These changes are consistent with a reduced density of NMDA receptors.|
|Internal ID Number:||1976785|
Binding, Competitive.drug effects
Cerebral Cortex.drug effects.metabolism
In Vitro Techniques
Rats, Inbred Strains
|Appears in Collections:||Journal articles|
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