Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10871
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPardoe, Heath Ren
dc.contributor.authorPell, Gaby Sen
dc.contributor.authorAbbott, David Fen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-16T00:26:56Z
dc.date.available2015-05-16T00:26:56Z
dc.date.issued2009-08-13en
dc.identifier.citationEpilepsia 2009; 50(12): 2586-92en
dc.identifier.govdoc19682030en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10871en
dc.description.abstractQuantitative measurement of hippocampal volume using structural magnetic resonance imaging (MRI) is a valuable tool for detection and lateralization of mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE). We compare two automated hippocampal volume methodologies and manual hippocampal volumetry to determine which technique is most sensitive for the detection of hippocampal atrophy in mTLE.We acquired a three-dimensional (3D) volumetric sequence in 10 patients with left-lateralized mTLE and 10 age-matched controls. Hippocampal volumes were measured manually, and using the software packages Freesurfer and FSL-FIRST. The sensitivities of the techniques were compared by determining the effect size for average volume reduction in patients with mTLE compared to controls. The volumes and spatial overlap of the automated and manual segmentations were also compared.Significant volume reduction in affected hippocampi in mTLE compared to controls was detected by manual hippocampal volume measurement (p < 0.01, effect size 33.2%), Freesurfer (p < 0.01, effect size 20.8%), and FSL-FIRST (p < 0.01, effect size 13.6%) after correction for brain volume. Freesurfer correlated reasonably (r = 0.74, p < 0.01) with this manual segmentation and FSL-FIRST relatively poorly (r = 0.47, p < 0.01). The spatial overlap between manual and automated segmentation was reduced in affected hippocampi, suggesting the accuracy of automated segmentation is reduced in pathologic brains.Expert manual hippocampal volumetry is more sensitive than both automated methods for the detection of hippocampal atrophy associated with mTLE. In our study Freesurfer was the most sensitive to hippocampal atrophy in mTLE and could be used if expert manual segmentation is not available.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAtrophy.classification.pathologyen
dc.subject.otherBrain.pathologyen
dc.subject.otherBrain Mapping.methodsen
dc.subject.otherEpilepsy, Temporal Lobe.diagnosis.pathologyen
dc.subject.otherFemaleen
dc.subject.otherFunctional Laterality.physiologyen
dc.subject.otherHippocampus.pathologyen
dc.subject.otherHumansen
dc.subject.otherImage Enhancementen
dc.subject.otherImage Interpretation, Computer-Assisteden
dc.subject.otherImaging, Three-Dimensionalen
dc.subject.otherMagnetic Resonance Imaging.methods.statistics & numerical dataen
dc.subject.otherMaleen
dc.subject.otherSclerosis.pathologyen
dc.titleHippocampal volume assessment in temporal lobe epilepsy: How good is automated segmentation?en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsiaen
dc.identifier.affiliationBrain Research Institute, Florey Neuroscience Institutes (Austin), Melbourne, Victoria, Australiaen
dc.identifier.doi10.1111/j.1528-1167.2009.02243.xen
dc.description.pages2586-92en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19682030en
dc.type.austinJournal Articleen
local.name.researcherAbbott, David F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

20
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.