Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10864
Title: Renal blood flow during acute renal failure in man.
Authors: Prowle, John R;Ishikawa, Ken;May, Clive N;Bellomo, Rinaldo
Affiliation: Intensive Care Unit, Austin Hospital, Heidelberg, Vic, Australia.
Issue Date: 31-Jul-2009
Citation: Blood Purification 2009; 28(3): 216-25
Abstract: In the critically ill, ischemia secondary to decreased renal blood flow (RBF) is believed to be central to the pathogenesis of acute renal failure (ARF); however, the scientific basis for this conclusion has not been systematically evaluated.Systematic interrogation of the Pubmed database, and screening bibliographies of retrieved reports, for studies of human ARF where RBF was measured.Thirty-two articles published between 1944 and 2008 describing RBF in 373 patients with ARF were identified. Overall, mean RBF during ARF was 387 ml/min. It was 329 ml/min when estimated by clearance-based techniques (15 studies) and 471 ml/min when measured with nonclearance-based techniques (17 studies). Only 46 patients had measurements in the intensive care unit where mean RBF was 306 ml/min. Normal RBF was reported in 14 publications, mean 1,192 ml/min.Limited information is available on RBF during ARF in the critically ill. Measurements in contemporary patients are required to further our understanding of this condition.
Internal ID Number: 19648741
URI: http://ahro.austin.org.au/austinjspui/handle/1/10864
DOI: 10.1159/000230813
URL: http://www.ncbi.nlm.nih.gov/pubmed/19648741
Type: Journal Article
Subjects: Acute Kidney Injury.etiology.physiopathology
Critical Illness
Female
Humans
Ischemia.complications.physiopathology
Kidney.blood supply
Male
Renal Circulation
Appears in Collections:Journal articles

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