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Title: Identification of four different CD46 (MCP) molecules with anti-peptide antibodies.
Authors: Purcell, D F;Jonstone, R W;McKenzie, Ian F C
Affiliation: Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 31-Oct-1991
Citation: Biochemical and Biophysical Research Communications; 180(2): 1091-7
Abstract: Four protein isoforms of the human CD46 molecule (MCP) have been identified using rabbit antisera against synthetic peptides corresponding to predicted cytoplasmic carboxyl-terminal sequences. Two different cytoplasmic tails, CD46 CYT 1 and CD46 CYT 2, were detected in CD46 molecules isolated from almost every cell type examined. Bands of 56 and 66 kDa were obtained from SDS-PAGE analyses of various cell types with both CYT 1 and CYT 2 antisera, which indicated that the size polymorphism of the CD46 molecule is not due to variations in the cytoplasmic tail and that each species contained two different sized molecules.
Internal ID Number: 1953714
Type: Journal Article
Subjects: Amino Acid Sequence
Antigen-Antibody Complex
Antigens, CD.analysis.genetics.immunology
Antigens, CD46
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Membrane Glycoproteins.analysis.genetics.immunology
Molecular Sequence Data
Peptides.chemical synthesis.immunology
Appears in Collections:Journal articles

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