Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10827
Title: The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury.
Authors: Haase-Fielitz, Anja;Bellomo, Rinaldo;Devarajan, Prasad;Bennett, Michael R;Story, David A;Matalanis, George;Frei, Ulrich;Dragun, Duska;Haase, Michael
Affiliation: Department of Intensive Care, Austin Health, Melbourne, Australia.
Issue Date: 27-May-2009
Citation: Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association 2009; 24(11): 3349-54
Abstract: In adult cardiac surgery, the predictive value for AKI of neutrophil gelatinase-associated lipocalin (NGAL) appears to have wide variability. The choice of definition of acute kidney injury (AKI) might, at least in part, account for such variability.In a prospective study of 100 adult cardiac surgery patients, we assessed the value of postoperative plasma NGAL in predicting AKI according to the degree of severity used for its definition.The predictive value of plasma NGAL varied according to the AKI definition used and was higher for more severe AKI (increase in creatinine >50%: mean AUC-ROC 0.79 +/- 0.01) compared to less severe AKI (>25%: mean AUC-ROC 0.65 +/- 0.02); P = 0.001. The discriminatory ability of NGAL for AKI also increased with increasing RIFLE classes (AUC-ROC R: 0.72, I: 0.79, F: 0.80) or AKIN stages (AUC-ROC 1: 0.75, 2: 0.78, 3: 0.81); P = 0.015. It was highest for the prediction of renal replacement therapy (AUC-ROC: 0.83).In adult cardiac surgery patients, the predictive value of NGAL increases with grade of AKI. This observation needs to be taken into account when interpreting any future studies of this biomarker.
Internal ID Number: 19474273
URI: http://ahro.austin.org.au/austinjspui/handle/1/10827
DOI: 10.1093/ndt/gfp234
URL: http://www.ncbi.nlm.nih.gov/pubmed/19474273
Type: Journal Article
Subjects: Acute Kidney Injury.blood.classification
Acute-Phase Proteins
Adult
Aged
Area Under Curve
Cardiac Surgical Procedures
Creatinine.blood
Female
Humans
Lipocalins.blood
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Proto-Oncogene Proteins.blood
ROC Curve
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.