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Title: The elevated expression of calcitonin receptor by cells recruited into the endothelial layer and neo-intima of atherosclerotic plaque.
Authors: Wookey, Peter J;Zulli, Anthony;Hare, David L
Department of Cardiology, University of Melbourne, Austin Health, Austin Campus, Studley Road, Heidelberg, VIC, 3084, Australia
Issue Date: 29-Apr-2009
Citation: Histochemistry and Cell Biology 2009; 132(2): 181-9
Abstract: Calcitonin receptor-immunoreactive (CTR-ir) endothelial and foam cells were identified in atherosclerotic plaque within the abdominal and thoracic aortas of rabbits fed a cholesterol-supplemented diet. Initially, cells within the endothelial layers of nascent atherosclerotic plaque of arteries were also CD34-positive, a marker of precursor cells of the haematopoietic lineage. In a further rabbit model with more advanced cardiovascular disease, CTR-ir cells were located deeper within the plaque as well as within the endothelial layer overlying the neo-intima. Finally, in the third model, in which the 4-week period on the atherogenic diet was followed by a 12-week period of regression on a normal chow diet, during which serum cholesterol levels returned to the normal range, CTR-ir was markedly reduced in the stabilized fibrous cap of plaque. Thus, the expression of CTR is associated with the early cellular events involved in plaque formation and is down-regulated as stabilisation of plaque progresses in the process of healing.
Internal ID Number: 19404669
DOI: 10.1007/s00418-009-0600-6
Type: Journal Article
Subjects: Animals
Diet, Atherogenic
Disease Models, Animal
Receptors, Calcitonin.biosynthesis
Tunica Intima.metabolism.pathology
Appears in Collections:Journal articles

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