Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10798
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dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorMcLean, Catriona A-
dc.contributor.authorReardon, K-
dc.contributor.authorBoyd, A-
dc.contributor.authorLewis, V-
dc.contributor.authorKlug, G-
dc.contributor.authorJones, G-
dc.contributor.authorBaxendale, D-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorCollins, S J-
dc.date.accessioned2015-05-16T00:21:58Z
dc.date.available2015-05-16T00:21:58Z
dc.date.issued2009-03-29-
dc.identifier.citationJournal of Neurology, Neurosurgery, and Psychiatry 2009; 80(9): 998-1001en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10798en
dc.description.abstractBrain amyloid imaging using positron emission tomography (PET) is of increasing importance in the premortem evaluation of dementias, particularly in relation to Alzheimer disease (AD). The purpose of this study was to explore the premortem diagnostic utility of (11)C-PiB PET in sporadic Creutzfeldt-Jakob disease (CJD).Two patients, 72 and 59 years old, underwent evaluation for rapidly progressive cognitive decline, dying after illness durations of 5 and 7 months, respectively. As part of their comprehensive assessment, (18)F-FDG PET and (11)C-PiB PET studies were performed approximately 2-4 weeks prior to death, and the brain regional distributions compared with those from cohorts of healthy controls (HC) and AD patients.Routine investigations, including brain MRI scans, revealed changes typical of sporadic CJD, with the diagnosis confirmed at autopsy in both patients. The (18)F-FDG PET showed global hypometabolism in one patient and thalamic and frontal hypometabolism with unexpected hypermetabolism in the dentate nuclei of the cerebellum in the other. Neither patient displayed cerebral cortical (11)C-PiB PET retention above the levels observed in HC.No grey-matter (11)C-PiB retention was observed in two pathologically confirmed cases of typical sporadic CJD. We speculate that low PrP plaque density and small plaque size, as well as a relatively low affinity of the radioligand, explain the absence of (11)C-PiB retention. More studies to validate this hypothesis are warranted.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherBenzothiazoles.diagnostic useen
dc.subject.otherBrain.pathologyen
dc.subject.otherBrain Chemistry.physiologyen
dc.subject.otherCodon.geneticsen
dc.subject.otherCreutzfeldt-Jakob Syndrome.metabolism.pathology.radionuclide imagingen
dc.subject.otherFatal Outcomeen
dc.subject.otherFemaleen
dc.subject.otherFluorodeoxyglucose F18.diagnostic useen
dc.subject.otherHumansen
dc.subject.otherImmunohistochemistryen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMiddle Ageden
dc.subject.otherPositron-Emission Tomographyen
dc.subject.otherRadiopharmaceuticals.diagnostic useen
dc.title11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of neurology, neurosurgery, and psychiatryen
dc.identifier.affiliationDepartment of Nuclear Medicine, Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Vic. 3084, Australiaen
dc.identifier.doi10.1136/jnnp.2008.171496en
dc.description.pages998-1001en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19332421en
dc.type.contentTexten
dc.type.austinJournal Articleen
local.name.researcherMasters, Colin L
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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