Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/10798
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Villemagne, Victor L | - |
dc.contributor.author | McLean, Catriona A | - |
dc.contributor.author | Reardon, K | - |
dc.contributor.author | Boyd, A | - |
dc.contributor.author | Lewis, V | - |
dc.contributor.author | Klug, G | - |
dc.contributor.author | Jones, G | - |
dc.contributor.author | Baxendale, D | - |
dc.contributor.author | Masters, Colin L | - |
dc.contributor.author | Rowe, Christopher C | - |
dc.contributor.author | Collins, S J | - |
dc.date.accessioned | 2015-05-16T00:21:58Z | |
dc.date.available | 2015-05-16T00:21:58Z | |
dc.date.issued | 2009-03-29 | - |
dc.identifier.citation | Journal of Neurology, Neurosurgery, and Psychiatry 2009; 80(9): 998-1001 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/10798 | en |
dc.description.abstract | Brain amyloid imaging using positron emission tomography (PET) is of increasing importance in the premortem evaluation of dementias, particularly in relation to Alzheimer disease (AD). The purpose of this study was to explore the premortem diagnostic utility of (11)C-PiB PET in sporadic Creutzfeldt-Jakob disease (CJD).Two patients, 72 and 59 years old, underwent evaluation for rapidly progressive cognitive decline, dying after illness durations of 5 and 7 months, respectively. As part of their comprehensive assessment, (18)F-FDG PET and (11)C-PiB PET studies were performed approximately 2-4 weeks prior to death, and the brain regional distributions compared with those from cohorts of healthy controls (HC) and AD patients.Routine investigations, including brain MRI scans, revealed changes typical of sporadic CJD, with the diagnosis confirmed at autopsy in both patients. The (18)F-FDG PET showed global hypometabolism in one patient and thalamic and frontal hypometabolism with unexpected hypermetabolism in the dentate nuclei of the cerebellum in the other. Neither patient displayed cerebral cortical (11)C-PiB PET retention above the levels observed in HC.No grey-matter (11)C-PiB retention was observed in two pathologically confirmed cases of typical sporadic CJD. We speculate that low PrP plaque density and small plaque size, as well as a relatively low affinity of the radioligand, explain the absence of (11)C-PiB retention. More studies to validate this hypothesis are warranted. | en |
dc.language.iso | en | en |
dc.subject.other | Aged | en |
dc.subject.other | Benzothiazoles.diagnostic use | en |
dc.subject.other | Brain.pathology | en |
dc.subject.other | Brain Chemistry.physiology | en |
dc.subject.other | Codon.genetics | en |
dc.subject.other | Creutzfeldt-Jakob Syndrome.metabolism.pathology.radionuclide imaging | en |
dc.subject.other | Fatal Outcome | en |
dc.subject.other | Female | en |
dc.subject.other | Fluorodeoxyglucose F18.diagnostic use | en |
dc.subject.other | Humans | en |
dc.subject.other | Immunohistochemistry | en |
dc.subject.other | Magnetic Resonance Imaging | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Positron-Emission Tomography | en |
dc.subject.other | Radiopharmaceuticals.diagnostic use | en |
dc.title | 11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Journal of neurology, neurosurgery, and psychiatry | en |
dc.identifier.affiliation | Department of Nuclear Medicine, Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Vic. 3084, Australia | en |
dc.identifier.doi | 10.1136/jnnp.2008.171496 | en |
dc.description.pages | 998-1001 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/19332421 | en |
dc.type.content | Text | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Masters, Colin L | |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.