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dc.contributor.authorHowes, L Gen
dc.contributor.authorConway, Elizabeth Len
dc.contributor.authorPhillips, P Aen
dc.contributor.authorBroadbear, Jen
dc.contributor.authorDrummer, Olaf Hen
dc.contributor.authorLouis, William Jen
dc.identifier.citationBiopharmaceutics & Drug Disposition; 12(6): 447-55en
dc.description.abstractEnalapril and hydrochlorothiazide (HCT) are established single agent treatments for mild hypertension and cardiac failure and are a potent combination in more severe or resistant cases. We have compared the pharmacokinetics of enalaprilat (the active metabolite of enalapril) and HCT in a four-way comparison of a combination tablet of enalapril (10 mg)/HCT (25 mg) with a single dose of an enalapril tablet (10 mg), a single dose of a HCT tablet (25 mg) and simultaneous administration of separate tablets of enalapril (10 mg) and HCT (25 mg) in normotensive volunteers (n = 12, 21-26 years). Each subject received all four treatments and the study was conducted as a randomized, latin square, open design with at least 1 week washout between studies. Overall, HCT was bioequivalent under all conditions and enalaprilat was bioequivalent when given in combination with HCT either as one tablet or as two separate tablets. However, when given with HCT, the mean AUC and Cmax of enalaprilat were reduced up to 20 per cent compared with enalapril administered alone. This is unlikely to be of clinical significance as the differences did not reach statistical significance and the total enalaprilat excreted in the urine over 96 h was similar after all treatments.en
dc.subject.otherDrug Combinationsen
dc.subject.otherEnalapril.administration & dosage.pharmacokineticsen
dc.subject.otherHydrochlorothiazide.administration & dosage.pharmacokineticsen
dc.titlePharmacokinetic comparison of a combination tablet of enalapril and hydrochlorothiazide with enalapril and hydrochlorothiazide tablets administered together and separately.en
dc.typeJournal Articleen
dc.identifier.journaltitleBiopharmaceutics & drug dispositionen
dc.identifier.affiliationDepartment of Clinical Pharmacology and Therapeutics, Austin Hospital, Heidelberg, Victoria, Australiaen
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