Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10793
Title: Gastrin-releasing peptide: different forms, different functions.
Authors: Ischia, Joseph J;Patel, Oneel;Shulkes, Arthur;Baldwin, Graham S
Affiliation: Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia.
Issue Date: 2-Jan-2009
Citation: Biofactors (oxford, England); 35(1): 69-75
Abstract: All forms of the neuropeptide gastrin-releasing peptide (GRP) are derived from the precursor proGRP1-125. Amidated GRP18-27, which together with amidated GRP1-27 was long thought to be the only biologically relevant product of the GRP gene, is involved in a multitude of physiological functions and acts as a mitogen, morphogen, and proangiogenic factor in certain cancers. Recently, GRP has been implicated in several psychiatric conditions, in the maintenance of circadian rhythm, in spinal transmission of the itch sensation, and in inflammation and wound repair. The actions of GRP are mediated by the GRP receptor. Over the last decade, nonamidated peptides derived from proGRP, such as the glycine-extended form GRP18-28 and recombinant and synthetic fragments from proGRP31-125, have been shown to be biologically active in a range of tissues and in cancer cell lines. While GRP18-28 acts via the GRP receptor, the identity of the receptor for proGRP31-125 and its fragments has not yet been established. Nonamidated fragments are also present in normal tissues and in various cancers. In fact, proGRP31-98 is the most sensitive serum biomarker in patients with small cell lung cancer and is a significant predictor of poor survival in patients with advanced prostate cancer.
Internal ID Number: 19319848
URI: http://ahro.austin.org.au/austinjspui/handle/1/10793
DOI: 10.1002/biof.10
URL: http://www.ncbi.nlm.nih.gov/pubmed/19319848
Type: Journal Article
Subjects: Animals
Gastrin-Releasing Peptide.genetics.metabolism
Humans
Models, Genetic
Neoplasms.metabolism
Peptide Fragments.genetics.metabolism
Peptides.metabolism
Receptors, Bombesin.metabolism
Recombinant Proteins.genetics.metabolism
Appears in Collections:Journal articles

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