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Title: 18F-FDG-PET imaging of a benign neurofibroma masquerading as metastatic oesophageal carcinoma.
Authors: Azad, Arun A;Chong, Geoffrey;Tauro, A;Aly, Ahmad;Tebbutt, Niall C
Affiliation: Ludwig Institute Oncology Unit, University of Melbourne, Austin Hospital, Austin Health, Heidelberg, Victoria, Australia, Australia
Issue Date: 19-Mar-2009
Citation: Medical Oncology (northwood, London, England) 2009; 27(2): 230-2
Abstract: We present the case of a 65-year-old male with squamous cell carcinoma of the thoracic oesophagus on a background of neurofibromatosis type 1. On computed tomography, he was noted to have a large left-sided superior mediastinal mass. Initially, this mass was thought to be metastatic lymphadenopathy; however, it did not display fluorodeoxyglucose uptake on positron emission tomography. Subsequent biopsy confirmed the mass to be a neurofibroma and the patient commenced definitive chemo-radiation. Positron emission tomography had a major impact on management since the presumed lymph node disease was not included in the radiation field. In addition, positron emission tomography altered prognostic stratification since lymph node involvement is a poor prognostic factor in oesophageal cancer. We could only identify one other case in the English literature in which positron emission tomography was used to distinguish metastatic carcinoma from a neurofibroma, although there are a number of reports that describe the utility of positron emission tomography in differentiating benign neurofibromas from malignant connective tissue tumours.
Internal ID Number: 19296240
DOI: 10.1007/s12032-009-9196-x
Type: Journal Article
Subjects: Aged
Diagnosis, Differential
Esophageal Neoplasms.diagnosis.radionuclide imaging.secondary
Fluorodeoxyglucose F18.diagnostic use
Neurofibroma.diagnosis.radionuclide imaging
Positron-Emission Tomography
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