Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10767
Title: Preproneuropeptide Y Messenger Ribonucleic Acid in the Hypothalamic Arcuate Nucleus of the Rat is Increased by Food Deprivation or Dehydration.
Authors: O'Shea, R D;Gundlach, Andrew L
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Feb-1991
Citation: Journal of Neuroendocrinology; 3(1): 11-4
Abstract: The distribution of messenger ribonucleic acid (mRNA) encoding preproneuropeptide Y (prepro-NPY) in the hypothalamus of rats subjected to food deprivation or dehydration has been investigated by quantitative in situ hybridization. Levels of prepro-NPY mRNA in the arcuate nucleus (ARC) were selectively increased by both treatments. The very high concentration of prepro-NPY mRNA seen following 96 h of food deprivation had returned towards control levels after 24 h of refeeding. Levels of preprogalanin (prepro-GAL) mRNA throughout the hypothalamus were essentially unaffected by both regimes. These results demonstrate that hypothalamic NPY gene expression is regulated by peripheral metabolic status (and osmolality), and confirm the key physiological role of NPY in controlling ingestive behaviour.
Internal ID Number: 19215440
URI: http://ahro.austin.org.au/austinjspui/handle/1/10767
DOI: 10.1111/j.1365-2826.1991.tb00232.x
URL: http://www.ncbi.nlm.nih.gov/pubmed/19215440
Type: Journal Article
Appears in Collections:Journal articles

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