Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10765
Title: A neurologist's guide to genome-wide association studies.
Authors: Mullen, Saul A;Crompton, Douglas E;Carney, Patrick W;Helbig, Ingo;Berkovic, Samuel F
Affiliation: Epilepsy Research Centre and Department of Medicine (Neurology), University of Melbourne, Austin Health, 145 Studley Rd., Heidelberg, Victoria 3084, Australia.
Issue Date: 10-Feb-2009
Citation: Neurology; 72(6): 558-65
Abstract: Genome-wide association studies are utilized for gene discovery in common diseases. Genotypes of large groups of unrelated patients are compared to controls. This has become feasible due to the recent technical advances in genomics and convincing positive results are now regularly being published. This review is an accessible introduction to the genetic and technical knowledge needed to interpret such studies. Genome-wide association studies are being applied to many neurologic diseases. Here we use idiopathic generalized epilepsy as an example to highlight the phenotyping, sample size, and statistical issues that must be addressed in such studies. These studies are likely to transform our understanding of complex neurologic diseases in the next few years.
Internal ID Number: 19204266
URI: http://ahro.austin.org.au/austinjspui/handle/1/10765
DOI: 10.1212/01.wnl.0000341942.29513.bd
URL: http://www.ncbi.nlm.nih.gov/pubmed/19204266
Type: Journal Article
Subjects: Chromosome Mapping.methods
Clinical Trials as Topic
Genetic Predisposition to Disease.epidemiology.genetics
Genome-Wide Association Study.methods
Humans
Nervous System Diseases.epidemiology.genetics
Polymorphism, Single Nucleotide.genetics
Appears in Collections:Journal articles

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