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|Title:||Dravet syndrome or genetic (generalized) epilepsy with febrile seizures plus?|
|Authors:||Scheffer, Ingrid E;Zhang, Yue-Hua;Jansen, Floor E;Dibbens, Leanne M|
|Affiliation:||Department of Medicine, The University of Melbourne, Austin Health, Victoria, Australia. email@example.com|
|Citation:||Brain & Development 2009; 31(5): 394-400|
|Abstract:||Dravet syndrome and genetic epilepsy with febrile seizures plus (GEFS+) can both arise due to mutations of SCN1A, the gene encoding the alpha 1 pore-forming subunit of the sodium channel. GEFS+ refers to a familial epilepsy syndrome where at least two family members have phenotypes that fit within the GEFS+ spectrum. The GEFS+ spectrum comprises a range of mild to severe phenotypes varying from classical febrile seizures to Dravet syndrome. Dravet syndrome is a severe infantile onset epilepsy syndrome with multiple seizure types, developmental slowing and poor outcome. More than 70% of patients with Dravet syndrome have mutations of SCN1A; these include both truncation and missense mutations. In contrast, only 10% of GEFS+ families have SCN1A mutations and these comprise missense mutations. GEFS+ has also been associated with mutations of genes encoding the sodium channel beta 1 subunit, SCN1B, and the GABA(A) receptor gamma 2 subunit, GABRG2. The phenotypic heterogeneity that is characteristic of GEFS+ families is likely to be due to modifier genes. Interpretation of the significance of a SCN1A missense mutation requires a thorough understanding of the phenotypes in the GEFS+ spectrum whereas a de novo truncation mutation is likely to be associated with a severe phenotype. Early recognition of Dravet syndrome is important as aggressive control of seizures may improve developmental outcome.|
|Internal ID Number:||19203856|
Genetic Predisposition to Disease.genetics
NAV1.1 Voltage-Gated Sodium Channel
Nerve Tissue Proteins.genetics
Voltage-Gated Sodium Channel beta-1 Subunit
|Appears in Collections:||Journal articles|
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