Please use this identifier to cite or link to this item:
|Title:||A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design.|
|Authors:||Ebert, Lisa M;Liu, Yu Chih;Clements, Craig S;Robson, Neil C;Jackson, Heather M;Markby, Jessica L;Dimopoulos, Nektaria;Tan, Bee Shin;Luescher, Immanuel F;Davis, Ian D;Rossjohn, Jamie;Cebon, Jonathan S;Purcell, Anthony W;Chen, Weisan|
|Affiliation:||Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Austin Health, Heidelberg, Victoria, Australia.|
|Citation:||Cancer Research 2009; 69(3): 1046-54|
|Abstract:||The tumor antigen NY-ESO-1 is a promising cancer vaccine target. We describe here a novel HLA-B7-restricted NY-ESO-1 epitope, encompassing amino acids 60-72 (APRGPHGGAASGL), which is naturally presented by melanoma cells. The tumor epitope bound to HLA-B7 by bulging outward from the peptide-binding cleft. This bulged epitope was not an impediment to T-cell recognition, however, because four of six HLA-B7(+) melanoma patients vaccinated with NY-ESO-1 ISCOMATRIX vaccine generated a potent T-cell response to this determinant. Moreover, the response to this epitope was immunodominant in three of these patients and, unlike the T-cell responses to bulged HLA class I viral epitopes, the responding T cells possessed a remarkably broad TCR repertoire. Interestingly, HLA-B7(+) melanoma patients who did not receive the NY-ESO-1 ISCOMATRIX vaccine rarely generated a spontaneous T-cell response to this cryptic epitope, suggesting a lack of priming of such T cells in the natural anti-NY-ESO-1 response, which may be corrected by vaccination. Together, our results reveal several surprising aspects of antitumor immunity and have implications for cancer vaccine design.|
|Internal ID Number:||19176376|
Amino Acid Sequence
Amino Acid Substitution
Cancer Vaccines.immunology.therapeutic use
Cell Line, Tumor
Molecular Sequence Data
|Appears in Collections:||Journal articles|
Files in This Item:
There are no files associated with this item.
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.