Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10735
Title: Peptide processing and biology in human disease.
Authors: Kovac, Suzana;Shulkes, Arthur;Baldwin, Graham S
Affiliation: University of Melbourne, Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.
Issue Date: 1-Feb-2009
Citation: Current Opinion in Endocrinology, Diabetes, and Obesity; 16(1): 79-85
Abstract: To describe recent advances in the processing of gastrointestinal hormones, and the consequences for human disease of mutations in the enzymes involved.Although gastrointestinal prohormones were long regarded as devoid of biological activity, recent data indicate that the prohormones for both gastrin and gastrin-releasing peptide are bioactive, through different receptors from the mature hormones. Mutations in the family of prohormone convertases responsible for the initial steps in the processing of gastrointestinal hormones are associated with several different pathophysiological conditions in humans.Human mutational studies, when taken together with the phenotypes observed in mice deficient in the prohormone convertases, emphasize the crucial importance of the processing enzymes in mammalian biology. Although the phenotypes may often be ascribed to defective production of a mature hormone or growth factor, the recognition that the precursors are independently bioactive suggests that the increased precursor concentrations may also contribute to the symptoms. The observation that the precursors often act through different receptors from the mature hormones may permit the development of precursor-selective antagonists for therapeutic use.
Internal ID Number: 19104240
URI: http://ahro.austin.org.au/austinjspui/handle/1/10735
DOI: 10.1097/MED.0b013e3283202555
URL: http://www.ncbi.nlm.nih.gov/pubmed/19104240
Type: Journal Article
Subjects: Animals
Furin.genetics.physiology
Gastrin-Releasing Peptide.physiology
Gastrins.physiology
Gastrointestinal Diseases.enzymology.genetics.physiopathology
Gastrointestinal Hormones.physiology
Hormones.physiology
Humans
Mice
Mice, Knockout
Models, Animal
Mutation
Peptides.genetics.metabolism.physiology
Proprotein Convertases.physiology
Protein Precursors.physiology
Appears in Collections:Journal articles

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