Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10717
Title: Serial functional imaging poststroke reveals visual cortex reorganization.
Authors: Brodtmann, Amy;Puce, Aina;Darby, David G;Donnan, Geoffrey A
Affiliation: National Stroke Research Institute, Austin Health, University of Melbourne, Heidelberg, Melbourne, Australia
amyb@alphalink.com.au
Issue Date: 24-Nov-2008
Citation: Neurorehabilitation and Neural Repair 2008; 23(2): 150-9
Abstract: Visual cortical reorganization following injury remains poorly understood. The authors performed serial functional magnetic resonance imaging (fMRI) on patients with visual cortex infarction to evaluate early and late striate, ventral, and dorsal extrastriate cortical activation.Patients were studied with fMRI within 10 days and at 6 months. The authors used a high-level visual activation task designed to activate the ventral extrastriate cortex. These data were compared to those of age-appropriate healthy control participants.The results from 24 healthy control individuals (mean age 65.7 +/- SE 3.6 years, range 32-89) were compared to those from 5 stroke patients (mean age 73.8 +/- SE 7 years, range 49-86). Patients had infarcts involving the striate and ventral extrastriate cortex. Patient activation patterns were markedly different to controls. Bilateral striate and ventral extrastriate activation was reduced at both sessions, but dorsal extrastriate activated voxel counts remained comparable to controls. Conversely, mean percent magnetic resonance signal change increased in dorsal sites.These data provide strong evidence of bilateral poststroke functional depression of striate and ventral extrastriate cortices. Possible utilization or surrogacy of the dorsal visual system was demonstrated following stroke. This activity could provide a target for novel visual rehabilitation therapies.
Internal ID Number: 19029284
URI: http://ahro.austin.org.au/austinjspui/handle/1/10717
DOI: 10.1177/1545968308321774
URL: http://www.ncbi.nlm.nih.gov/pubmed/19029284
Type: Journal Article
Subjects: Adult
Aged
Aged, 80 and over
Brain Mapping
Disability Evaluation
Functional Laterality.physiology
Humans
Image Processing, Computer-Assisted.methods
Magnetic Resonance Imaging
Middle Aged
Neuronal Plasticity.physiology
Neuropsychological Tests
Photic Stimulation
Predictive Value of Tests
Recovery of Function.physiology
Stroke.pathology.physiopathology
Vision Disorders.etiology.pathology.physiopathology
Visual Cortex.blood supply.pathology.physiopathology
Visual Pathways.pathology.physiopathology
Appears in Collections:Journal articles

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