Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10703
Title: Comparison of inflammation in the brain and spinal cord following mechanical injury.
Authors: Batchelor, Peter Egerton;Tan, Simon;Wills, Taryn E;Porritt, Michelle J;Howells, David William
Affiliation: Department of Medicine, University of Melbourne, Austin Health, Victoria, Australia.
Issue Date: 1-Oct-2008
Citation: Journal of Neurotrauma; 25(10): 1217-25
Abstract: Inflammation in the CNS predominantly involves microglia and macrophages, and is believed to be a significant cause of secondary injury following trauma. This study compares the microglial and macrophage response in the rat brain and spinal cord following discrete mechanical injury to better appreciate the degree to which these cells could contribute to secondary damage in these areas. We find that, 1 week after injury, the microglial and macrophage response is significantly greater in the spinal cord compared to the brain. This is the case for injuries to both gray and white matter. In addition, we observed a greater inflammatory response in white matter compared to gray matter within both the brain and spinal cord. Because activated microglia and macrophages appear to be effectors of secondary damage, a greater degree of inflammation in the spinal cord is likely to result in more extensive secondary damage. Tissue saving strategies utilizing anti-inflammatory treatments may therefore be more useful in traumatic spinal cord than brain injury.
Internal ID Number: 18986223
URI: http://ahro.austin.org.au/austinjspui/handle/1/10703
DOI: 10.1089/neu.2007.0308
URL: http://www.ncbi.nlm.nih.gov/pubmed/18986223
Type: Journal Article
Subjects: Animals
Anti-Inflammatory Agents.pharmacology.therapeutic use
Antigens, CD11b.analysis.metabolism
Biological Markers.analysis.metabolism
Brain.immunology.pathology.physiopathology
Brain Injuries.immunology.pathology.physiopathology
Disease Models, Animal
Encephalitis.immunology.pathology.physiopathology
Female
Gliosis.immunology.pathology.physiopathology
Macrophages.immunology.pathology
Microglia.immunology.pathology
Myelitis.immunology.pathology.physiopathology
Nerve Fibers, Myelinated.immunology.pathology
Neuroprotective Agents.pharmacology.therapeutic use
Rats
Rats, Inbred F344
Spinal Cord.immunology.pathology.physiopathology
Time Factors
Appears in Collections:Journal articles

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