Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10689
Title: Visual recognition memory. Neurophysiological evidence for the role of temporal white matter in man.
Authors: Puce, Aina;Andrewes, D G;Berkovic, Samuel F;Bladin, Peter F
Affiliation: Department of Neurology, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Aug-1991
Citation: Brain : A Journal of Neurology; 114 ( Pt 4)(): 1647-66
Abstract: A novel event-related potential (ERP) elicited by a visuospatial recognition memory task was recorded in 20 patients with temporal lobe epilepsy using depth electrodes sited in the temporal lobes. The ERPs comprised two components, an N400 and a P600, and were similar in morphology to the previously reported ERP to verbal recognition memory tasks. The two ERP components in both verbal and visuospatial tasks were dependent on stimulus type and our data suggest that they do not simply represent delayed P300 ERP responses. In 17/20 patients robust, reliable bilaterally present ERPs were elicited by both verbal and visuospatial memory tasks. N400 amplitude was larger in response to novel stimuli, whereas P600 amplitude was larger to repeated stimuli. P600 amplitude was larger in the right temporal lobe to both visuospatial and verbal stimulus material. N400 and P600 latencies did not vary with task, stimulus type or side of recording. In 3/20 patients, no ERPs were elicited by either memory task. In all 3 cases, unilateral temporal white matter abnormalities were demonstrated by magnetic resonance imaging. Behavioural measures, expressed in the form of standardized accuracy scores, did not differ from those of a normal control group, and hence are unlikely to account for the abnormalities in ERPs. These results are discussed with reference to the primate visual recognition memory pathway and suggest that ERPs to recognition memory tasks are generated by an interaction between the two homologous inferotemporal recognition memory pathways.
Internal ID Number: 1884171
URI: http://ahro.austin.org.au/austinjspui/handle/1/10689
URL: http://www.ncbi.nlm.nih.gov/pubmed/1884171
Type: Journal Article
Subjects: Adult
Analysis of Variance
Behavior
Electrophysiology
Epilepsy, Temporal Lobe.diagnosis.physiopathology
Evoked Potentials, Visual.physiology
Female
Humans
Magnetic Resonance Imaging
Male
Models, Neurological
Neuropsychological Tests
Pattern Recognition, Visual.physiology
Space Perception.physiology
Temporal Lobe.pathology.physiology
Visual Perception.physiology
Appears in Collections:Journal articles

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