Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10617
Title: Diurnal blood pressure variation in quadriplegic chronic spinal cord injury patients.
Authors: Krum, Henry;Louis, William J;Brown, Douglas J;Jackman, G P;Howes, L G
Affiliation: Department of Clinical Pharmacology and Therapeutics, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Mar-1991
Citation: Clinical Science (london, England : 1979); 80(3): 271-6
Abstract: 1. Measurement of blood pressure and heart rate over a 24 h period was performed in 10 quadriplegic spinal cord injury patients and 10 immobilized, neurologically intact orthopaedic subjects by using the Spacelabs 90207 automated ambulatory monitoring system. 2. Systolic and diastolic blood pressure fell significantly at night in orthopaedic subjects but not in quadriplegic patients, and night-time blood pressures were similar in both groups. 3. Cumulative summation of differences from a reference value (cusum analysis) confirmed a markedly diminished diurnal blood pressure variation in the quadriplegic patients. 4. These findings could not be accounted for on the basis of blood pressure variations during chronic postural change. 5. Heart rate fell significantly at night in both groups. 6. The findings suggest that the increase in blood pressure during waking hours in neurologically intact subjects is a consequence of a diurnal variation in sympathetic activity (absent in quadriplegic patients with sympathetic decentralization) which is independent of changes in physical activity.
Internal ID Number: 1850688
URI: http://ahro.austin.org.au/austinjspui/handle/1/10617
URL: http://www.ncbi.nlm.nih.gov/pubmed/1850688
Type: Journal Article
Subjects: Adult
Blood Pressure.physiology
Circadian Rhythm
Female
Humans
Immobilization
Male
Middle Aged
Quadriplegia.physiopathology
Spinal Cord Injuries.physiopathology
Sympathetic Nervous System.physiopathology
Appears in Collections:Journal articles

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